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Showing 1–4 of 4 results
Advanced filters: Author: Tim Kükenshöner Clear advanced filters

  • Centriole biogenesis begins with self-assembly of SAS-6 proteins into 9-fold symmetrical ring polymers, which then stack into a cartwheel that scaffolds organelle formation. Here, the authors develop monobodies against Chlamydomonas reinhardtii SAS-6 and use X-ray crystallography, atomic force microscopy and cryo-electron microscopy to reveal insights into ring assembly and stacking.

    • Georgios N. Hatzopoulos
    • Tim Kükenshöner
    • Pierre Gönczy
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • Constitutive Btk signaling drives several B-cell cancers. Here the authors demonstrate key allosteric intramolecular interactions between the SH2 domain and the kinase domain of Btk, and propose an alternative approach for inhibition of both wild-type and tyrosine kinase inhibitor-resistant Btk.

    • Daniel P. Duarte
    • Allan J. Lamontanara
    • Oliver Hantschel
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • STAT3 is an attractive therapeutic target but its homology with other STAT proteins complicates the development of selective inhibitors. Here, the authors develop monobodies with high affinity and selectivity for STAT3 and show that they can interfere with cellular STAT3 activity.

    • Grégory La Sala
    • Camille Michiels
    • Oliver Hantschel
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • The Bcr-Abl tyrosine kinases p210 and p190 are linked to different leukemias and differ by the Dbl homology (DH) and Pleckstrin-homology (PH) domains. Here the authors characterize structures of the Bcr-Abl p210 DH and PH domains and find that the PH domain is important for the cellular localization and signaling network of p210.

    • Sina Reckel
    • Charlotte Gehin
    • Oliver Hantschel
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-14