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Showing 1–13 of 13 results
Advanced filters: Author: Tim Lämmermann Clear advanced filters

  • Leukocyte migration over two-dimensional surfaces is dependent on the integrin family of adhesion receptors, which couple the contractile force of the actomyosin cytoskeleton to the extracellular environment. In this study, all integrin heterodimers from mouse leukocytes were ablated and it is shown that integrins are not required for migration in 3D environments, in vitro and in vivo. Such non-adhesive migration renders leukocytes autonomous from the tissue environment.

    • Tim Lämmermann
    • Bernhard L. Bader
    • Michael Sixt
    Research
    Nature
    Volume: 453, P: 51-55

  • Dendritic cells (DCs) shape tolerogenic and pro-inflammatory immune responses by presenting antigens to T cells; their ability to localize in peripheral tissues and secondary lymphoid organs is crucial for these functions. This Review describes the different migratory pathways employed by subsets of DCs from distinct tissue sites, detailing their mechanistic basis and importance for maintaining health.

    • Tim Worbs
    • Swantje I. Hammerschmidt
    • Reinhold Förster
    Reviews
    Nature Reviews Immunology
    Volume: 17, P: 30-48

  • A number of costimulatory signals are critical to the activation and regulation of T cells, but how the availability or self-regulation of these occurs was previously unclear. Here the authors show a difference in the fate of ligands trogocytosed by CD28 or CTLA4 and link this to cellular control of costimulation.

    • Simon Zenke
    • Mauricio P. Sica
    • Jan C. Rohr
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18

  • Single-cell profiling and fate-mapping experiments in the developing brain of mice and humans show that microglia and meningeal macrophages originate from a common prenatal precursor, but that perivascular macrophages are derived postnatally from meningeal macrophages.

    • Takahiro Masuda
    • Lukas Amann
    • Marco Prinz
    Research
    Nature
    Volume: 604, P: 740-748

  • Microscale arrays of protein–polysaccharide clusters enable the functional characterization of human-neutrophil migration.

    • Tim Lämmermann
    News & Views
    Nature Biomedical Engineering
    Volume: 1, P: 1-2

  • Immune cells are generally considered to be able to move through tissues using nonadhesive amoeboid migration mechanics. Here, the authors show that, unlike other immune cells, mast cells do not use this method and instead are completely reliant on integrin–ECM interactions.

    • Lukas Kaltenbach
    • Paloma Martzloff
    • Tim Lämmermann
    ResearchOpen Access
    Nature Immunology
    Volume: 24, P: 915-924

  • Two-photon intravital imaging is used here to define the regulation of interstitial neutrophil migration at local sites of cell death upon sterile tissue injury and infection; leukotriene B4 (LTB4) is shown to act between neutrophils as a signal relay molecule that acts to enhance the radius of neutrophil recruitment within the inflamed interstitium, and also to control, in concert with integrin receptors, dense neutrophil clustering for tight wound seal formation.

    • Tim Lämmermann
    • Philippe V. Afonso
    • Ronald N. Germain
    Research
    Nature
    Volume: 498, P: 371-375

  • Migrating dendritic cells can adapt their adhesive properties to switch between integrin-dependent and -independent modes of migration. By modulating their actin polymerization dynamics, cells can maintain a steady migration speed through a changing environment.

    • Jörg Renkawitz
    • Kathrin Schumann
    • Michael Sixt
    Research
    Nature Cell Biology
    Volume: 11, P: 1438-1443