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Showing 1–4 of 4 results

Advanced filters: Author: Timo A. Nees Clear advanced filters

Role of TMEM100 in mechanically insensitive nociceptor un-silencing

Silent nociceptors remained enigmatic ever since they were first described decades ago. Here, Nees. et al. show that inflammation-induced upregulation of TMEM100 unsilences silent nociceptors, which triggers secondary mechanical pain hypersensitivity.

Timo A. Nees
Na Wang
Stefan G. Lechner
ResearchOpen Access05 Apr 2023
Nature Communications

Volume: 14, P: 1-17
Neuropathic pain caused by miswiring and abnormal end organ targeting

Longitudinal imaging of nerve fibres in mice reveals that reinnervation after nerve injury can lead to neuropathic pain, which is mediated through aberrant patterns of reinnervation in denervated areas by nociceptors.

Vijayan Gangadharan
Hongwei Zheng
Rohini Kuner
ResearchOpen Access25 May 2022
Nature

Volume: 606, P: 137-145
Intrinsically disordered intracellular domains control key features of the mechanically-gated ion channel PIEZO2

A key question in mechanobiology is how mechanical forces are transmitted to PIEZO ion channels. Here, Verkest et al. identify an intracellular channel domain that is required for the activation of PIEZO2 by cytoskeleton-transmitted forces.

Clement Verkest
Irina Schaefer
Stefan G. Lechner
ResearchOpen Access15 Mar 2022
Nature Communications

Volume: 13, P: 1-14
Relative importance of soil fertility and microtopography as CO₂ and CH₄ exchange drivers in a northern boreal fen ecosystem

Juha Mikola
Sari Juutinen
Mika Aurela
ResearchOpen Access12 Mar 2025
Scientific Reports

Volume: 15, P: 1-16