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Showing 1–16 of 16 results
Advanced filters: Author: Timon E. Adolph Clear advanced filters

  • Dietary lipids are linked to the development of inflammatory bowel diseases through unclear mechanisms. Here, the authors report that dietary polyunsaturated fatty acids trigger intestinal inflammation resembling aspects of Crohn’s disease, which is restricted by glutathione peroxidase 4 in the intestinal epithelium.

    • Lisa Mayr
    • Felix Grabherr
    • Timon E. Adolph
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • Th17 cells are critical players in the immunopathology of a range of autoimmune diseases. Here the authors implicate Hedgehog signaling in Th17 polarization and in the immunopathology of intestinal inflammation in murine models and suggest therapeutic targeting of Hedgehog signaling in the context of inflammatory bowel disease.

    • Joachim Hanna
    • Flavio Beke
    • Maike de la Roche
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18

  • This Review outlines how Western-style diets contribute to the rising incidence of chronic, noncommunicable diseases by converging on key mechanisms, including gut microbial rarefaction and chronic inflammation.

    • Timon E. Adolph
    • Herbert Tilg
    Reviews
    Nature Medicine
    Volume: 30, P: 2133-2147

  • Variation in ATG16L1, a protein involved in autophagy, confers risk for Crohn’s disease, but mice with hypomorphic ATG16L1 activity do not develop spontaneous intestinal inflammation; this study shows that autophagy compensates for endoplasmic reticulum stress — common in inflammatory bowel disease epithelium — specifically in Paneth cells, with Crohn’s-disease-like inflammation of the ileum originating from this cell type when both pathways are compromised.

    • Timon E. Adolph
    • Michal F. Tomczak
    • Richard S. Blumberg
    Research
    Nature
    Volume: 503, P: 272-276

  • Gut commensal bacteria and their metabolites can contribute to metabolic diseases. Qiao, Liu et al. reveal that expansion of Parabacteroides merdae attenuates experimental atherosclerosis.

    • Herbert Tilg
    • Timon E. Adolph
    News & Views
    Nature Metabolism
    Volume: 4, P: 1221-1222

  • A new report in Science by Ma and colleagues uncovers the interplay of microbiota-controlled bile acid metabolism and immune responses in the context of primary and metastatic liver tumours in mice. Their findings shed light on the gut–liver axis in hepatic malignancies.

    • Timon E. Adolph
    • Herbert Tilg
    News & Views
    Nature Reviews Gastroenterology & Hepatology
    Volume: 15, P: 584-586

  • Experimental and clinical evidence supports a role of metabolic perturbation in the development of gut inflammation in inflammatory bowel disease (IBD). This Review discusses the role of diet and metabolic inflammation in IBD, outlining key concepts and highlighting the links between metabolism and inflammation in IBD.

    • Timon E. Adolph
    • Moritz Meyer
    • Herbert Tilg
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 19, P: 753-767

  • This Review discusses how adipose tissue can regulate host immune function via the release of adipokines, including adiponectin, leptin and various cytokines. These adipokines contribute to immune responses and metabolic inflammation and can have both beneficial and detrimental effects on host physiology. In obesity, adipokine release can promote insulin resistance and cardiovascular diseases; as such, there is interest in targeting these mediators for therapy of various metabolic disorders.

    • Herbert Tilg
    • Gianluca Ianiro
    • Timon E. Adolph
    Reviews
    Nature Reviews Immunology
    Volume: 25, P: 250-265

  • In this Review, Dai, Stockwell, Kroemer, Tang and colleagues offer a comprehensive discussion of the molecular regulation of ferroptosis and highlight how this may be potentially leveraged for therapeutic benefit for disease treatment.

    • Enyong Dai
    • Xin Chen
    • Daolin Tang
    Reviews
    Nature Cell Biology
    Volume: 26, P: 1447-1457

  • A combination of cell line, transgenic mouse and human genetic data implicates a proinflammatory function of Dickkopf1 across malignant and non-malignant cells.

    • Nikolai P. Jaschke
    • Sophie Pählig
    • Tilman D. Rachner
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-13

  • Here, the authors describe how metabolic disorders, such as type 2 diabetes and nonalcoholic fatty liver disease, are driven by alterations in the composition of the intestinal microbiota and its metabolites, which translocate from the gut across a disrupted intestinal barrier and contribute to metabolic inflammation.

    • Herbert Tilg
    • Niv Zmora
    • Eran Elinav
    Reviews
    Nature Reviews Immunology
    Volume: 20, P: 40-54