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Showing 1–5 of 5 results
Advanced filters: Author: Timotheus Y. F. Halim Clear advanced filters

  • In the early stages of pancreatic ductal adenocarcinoma (PDAC) development, loss of ALDH1L2 expression elevates reactive oxygen species levels, driving accelerated acinar-to-ductal metaplasia. Decreased ALDH1L2 expression is accompanied by formate overflow, which can be used to monitor PDAC progression.

    • Marc Hennequart
    • Loic Mervant
    • Karen H. Vousden
    ResearchOpen Access
    Nature Metabolism
    P: 1-14

  • Antigen presentation in skull bone marrow by hematopoietic stem and progenitor cells induces myelopoiesis and generates CD4+ regulatory T cells in a mouse model of ependymoma, promoting immune tolerance. Treatment with anti-GM-CSF antibody has antitumor effects that are augmented by immunotherapy.

    • Elizabeth Cooper
    • David A. Posner
    • Richard J. Gilbertson
    ResearchOpen Access
    Nature Genetics
    Volume: 58, P: 317-328

  • BRCA1 driven breast cancer arises from luminal progenitor cells but how BRCA1 loss-of-function affects the luminal progenitor cell state during premalignant stages of the disease is still unclear. Here, the authors demonstrate an aberrant differentiation of luminal progenitors towards a partial secretory luminal cell phenotype that occurs in a Brca1 deficient mouse model of breast cancer at early stages of tumour initiation and in breast cells from BRCA1 carriers.

    • Karsten Bach
    • Sara Pensa
    • Walid T. Khaled
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11