In Drosophila, activation by Wingless results in cleavage of its Frizzled2 receptor and translocation of the C terminus (Fz2-C) from the postsynaptic density to the nuclei. Mosca and Schwarz find that nuclear Fz2-C entry requires the nuclear import factors Importin-β11 and Importin-α2. This pathway promotes postsynaptic development of the subsynaptic reticulum.
- Timothy J Mosca
- Thomas L Schwarz
