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Showing 1–8 of 8 results
Advanced filters: Author: Timothy J. Nott Clear advanced filters

  • Understanding the mechanism of gas-sorbent interactions at a molecular level is important for the design of improved gas storage materials. Here, the authors study the binding domains of carbon dioxide and acetylene in a tetra-amide functionalized metal-organic framework at crystallographic resolution.

    • Florian Moreau
    • Ivan da Silva
    • Martin Schröder
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-9

  • Membraneless organelles form as liquid droplets inside cells. These bodies are effectively a separate organic phase, with unique biochemical properties. Now, the solvent interior of membraneless organelles has been shown to have a significant effect on the properties and structure of biomolecules. In addition to selectively partitioning and trafficking proteins, they can melt DNA without using ATP.

    • Timothy J. Nott
    • Timothy D. Craggs
    • Andrew J. Baldwin
    Research
    Nature Chemistry
    Volume: 8, P: 569-575

  • To extract information from NMR experiments, the number of resonances in the spectrum along with characteristic features such as chemical shifts and intensities need to be identified. Here the authors present UnidecNMR, a computational method that identifies resonances in NMR spectra using deconvolution.

    • Charles Buchanan
    • Gogulan Karunanithy
    • Andrew J. Baldwin
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11

  • The cellular heterogeneity in brain obscures the identification of robust cellular regulatory networks. Here the authors integrate genome-wide chromosome conformation data from sorted neurons and glia, with transcriptomic and enhancer profiles, to characterize cell-type-specific gene regulatory landscapes in the human brain, and provide insights into cell-type-specific gene regulatory networks in brain disorders.

    • Benxia Hu
    • Hyejung Won
    • Daniel H. Geschwind
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • It remains critical to understand the genomic events in response to treatment of oesophageal adenocarcinoma (OAC). Here, the authors perform a multi-omics analysis of OAC patients from the DOCTOR phase II clinical trial, finding genomic features and immune clusters associated with survival.

    • Marjan M. Naeini
    • Felicity Newell
    • Nicola Waddell
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • The ability of methylarginine sites to serve as binding motifs for Tudor proteins, and the functional significance of this, is now becoming clear. Tudor proteins are thought to interact with methylated PIWI proteins and regulate the PIWI-interacting RNA pathway in the germ line.

    • Chen Chen
    • Timothy J. Nott
    • Tony Pawson
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 12, P: 629-642