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Showing 1–4 of 4 results
Advanced filters: Author: Timothy K. Turkalo Clear advanced filters

  • Mutations of ATRX are frequent in cancers that immortalize through the ALT (Alternative lengthening of telomeres) pathway. Here the authors show that ALT features are repressed in embryonic stem cells that lack ATRX but induced by continuous telomere instability triggered upon cell differentiation.

    • Timothy K. Turkalo
    • Antonio Maffia
    • Dirk Hockemeyer
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • It is challenging to analyse chromosomal rearrangements in heterogeneous solid cancers. Here the authors present HiDENSEC, a method to jointly infer absolute copy number, ploidy, tumor purity and large-scale rearrangements from Hi-C data. The increased statistical power afforded by joint inference enables novel insights into cancer genome evolution.

    • Dan Daniel Erdmann-Pham
    • Sanjit Singh Batra
    • Dirk Hockemeyer
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • Analysis of changes in functional groups of species and potential drivers of environmental change for protected areas across the world’s major tropical regions reveals large variation between reserves that have been effective and those experiencing an erosion of biodiversity, and shows that environmental changes immediately outside reserves are nearly as important as those inside in determining their ecological fate.

    • William F. Laurance
    • D. Carolina Useche
    • Franky Zamzani
    Research
    Nature
    Volume: 489, P: 290-294