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Showing 1–13 of 13 results
Advanced filters: Author: Timothy M. Johanson Clear advanced filters

  • MORC2, a chromatin remodeler involved in epigenetic silencing and DNA repair, is linked to cancer and neurological disorders when dysregulated. Here, the authors show that MORC2 binds DNA at multiple sites, clamps onto it, and induces compaction, a process regulated by its phosphorylation.

    • Winnie Tan
    • Jeongveen Park
    • Shabih Shakeel
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-22

  • Here the authors reveal that a neomorphic mutation in chromatin protein SMCHD1 enhances SMCHD1-mediated gene silencing, including at the FSHD disease-relevant locus, while depleting SMCHD1-mediated chromatin interactions, suggesting these SMCHD1 functions are unlinked.

    • Andres Tapia del Fierro
    • Bianca den Hamer
    • Marnie E. Blewitt
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-22

  • During differentiation, chromosome conformation is remodelled to support lineage-specific transcriptional programs. Here, the authors characterise chromosome conformational changes in B lymphocytes as they differentiate into plasma cells, and provide evidence that chromosome reconfiguration occurs prior to DNA replication and mitosis and guides gene expression that controls differentiation.

    • Wing Fuk Chan
    • Hannah D. Coughlan
    • Rhys S. Allan
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • Stably silenced genes with methylated CpG at the promoter are refractory to current CRISPR activation systems. Here the authors create a more robust activation system, TETact that recruits DNA-demethylating TET1 with transcriptional activators.

    • Wing Fuk Chan
    • Hannah D. Coughlan
    • Rhys S. Allan
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-9

  • There is increasing evidence that epigenetic mechanisms contribute to therapeutic resistance in cancer. Here the authors study AML patient samples and a mouse model of non-genetic resistance and find that transcriptional plasticity drives stable epigenetic resistance, and identify regulators of enhancer function as important modulators of resistance.

    • Charles C. Bell
    • Katie A. Fennell
    • Mark A. Dawson
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • B cell development is tightly regulated in a stepwise manner to ensure proper generation of repertoire diversity via somatic gene rearrangements. Here, the authors show that a transcription factor, Erg, functions at the earliest stage to critically control two downstream factors, Ebf1 and Pax5, for modulating this gene rearrangement process.

    • Ashley P. Ng
    • Hannah D. Coughlan
    • Warren S. Alexander
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • Analysis of humeri from fossils that span the fin-to-limb transition reveal that the change in the humerus shape is driven by both ecology and phylogeny, and is associated with functional trade-offs related to locomotor performance.

    • Blake V. Dickson
    • Jennifer A. Clack
    • Stephanie E. Pierce
    Research
    Nature
    Volume: 589, P: 242-245

  • Zhong et al. exploit allelic variations in mice to pinpoint the ‘heavy lifter’ transcription factor families governing the chromatin landscape of resting and activated T cells.

    • Timothy M. Johanson
    • Rhys S. Allan
    News & Views
    Nature Immunology
    Volume: 23, P: 3-4

  • Some immune cells undergo processes that pose unique challenges to the 3D organization of their genomes. These include antigen receptor rearrangement, clonal expansion and the contortion of their nuclei. Here, Allan and colleagues discuss the latest insights into these processes from a structural genomics perspective.

    • Timothy M. Johanson
    • Wing Fuk Chan
    • Rhys S. Allan
    Reviews
    Nature Reviews Immunology
    Volume: 19, P: 448-456