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Showing 1–11 of 11 results
Advanced filters: Author: Timothy M. Rawson Clear advanced filters
  • Stadler et al. evaluate the diagnostic value of urinary tract infection biomarker, nitrite, in predicting disease progression and treatment efficacy. The longitudinal measurement of nitrite in an in-vitro UTI distinguishes between amoxicillin-resistant and susceptible E. coli strains and correlates with bacterial colony-forming unit counts in-vitro and in clinical UTI.

    • Ellen V. Stadler
    • Alison Holmes
    • Timothy M. Rawson
    ResearchOpen Access
    Communications Medicine
    Volume: 5, P: 1-6
  • The use of decision-support systems based on artificial intelligence approaches in antimicrobial prescribing raises important moral questions. Adopting ethical frameworks alongside such systems can aid the consideration of infection-specific complexities and support moral decision-making to tackle antimicrobial resistance.

    • William J. Bolton
    • Cosmin Badea
    • Timothy M. Rawson
    Comments & Opinion
    Nature Machine Intelligence
    Volume: 4, P: 912-915
  • Antibiotic resistance is an emerging global danger. Reaching responsible prescribing decisions requires the integration of broad and complex information. Artificial intelligence tools could support decision-making at multiple levels, but building them needs a transparent co-development approach to ensure their adoption upon implementation.

    • Timothy M. Rawson
    • Raheelah Ahmad
    • Alison H. Holmes
    Comments & Opinion
    Nature Human Behaviour
    Volume: 3, P: 543-545
  • Coronavirus disease 2019 may have a complex long-term impact on antimicrobial resistance (AMR). Coordinated strategies at the individual, health-care and policy levels are urgently required to inform necessary actions to reduce the potential longer-term impact on AMR and on access to effective antimicrobials.

    • Timothy M. Rawson
    • Damien Ming
    • Alison H. Holmes
    Comments & Opinion
    Nature Reviews Microbiology
    Volume: 18, P: 409-410
  • There is considerable variability in antimicrobial pharmacokinetics and pharmacodynamics, which can pose challenges for treatment of infection and antimicrobial resistance development. In this Review, Holmes and colleagues discuss how precision antimicrobial therapy, including biosensors and individualized treatment, can contribute to antimicrobial stewardship.

    • Timothy M. Rawson
    • Richard C. Wilson
    • Alison H. Holmes
    Reviews
    Nature Reviews Microbiology
    Volume: 19, P: 747-758
  • Antimicrobial resistance (AMR) is a global health challenge that requires cross-disciplinary collaboration to mitigate its impact on human health. We discuss some of the topical advances in the field, highlighting the AMR collection, which brings attention to the problem of AMR and suboptimal antimicrobial use in human medicine.

    • Timothy M. Rawson
    • Luke SP Moore
    • Mohammed Lamorde
    EditorialOpen Access
    Communications Medicine
    Volume: 5, P: 1-2
  • Stadler et al. propose using existing technologies to link urinary biomarkers and antimicrobial drug levels for personalised treatment of urinary tract infections. This approach aims to enable real-time pharmacokinetic-pharmacodynamic monitoring and optimise individual antibiotic dosing.

    • Ellen V. Stadler
    • Alison Holmes
    • Timothy M. Rawson
    Comments & OpinionOpen Access
    Communications Medicine
    Volume: 5, P: 1-5