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Showing 1–2 of 2 results
Advanced filters: Author: Timothy N. Tiambeng Clear advanced filters

  • Top-down proteomics can provide unique insights into the biological variations of protein biomarkers but detecting low-abundance proteins in body fluids remains challenging. Here, the authors develop a nanoparticle-based top-down proteomics approach enabling enrichment and detailed analysis of cardiac troponin I in human serum.

    • Timothy N. Tiambeng
    • David S. Roberts
    • Ying Ge
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • The heterogenous nature and dynamics of endogenous protein complexes pose challenges for conventional structural biology techniques. Here, the authors develop a native nanoproteomics strategy for the enrichment and subsequent native top-down mass spectrometry (nTDMS) analysis of endogenous cardiac troponin (cTn) complex directly from human heart tissue.

    • Emily A. Chapman
    • David S. Roberts
    • Ying Ge
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-12