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Showing 1–22 of 22 results
Advanced filters: Author: Timothy R. McCulloch Clear advanced filters

  • How TNF regulates NK cell function and homeostasis is not fully understood. Here the authors investigate conditional knock out mice with TNFR1 and/or TNFR2 deficiency in NK cells upon bacterial infection, and identify that TNFR1 promotes cell death and impairs immunity while TNFR2 increases NK accumulation and enhances immunity.

    • Timothy R. McCulloch
    • Gustavo R. Rossi
    • Fernando Souza-Fonseca-Guimaraes
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • Type 2 immunity in the gut is regulated by an interplay between epithelial and immune cells. A recent Nature paper shows that pain receptors amplify this response by promoting the differentiation of epithelial tuft cells.

    • Timothy R. McCulloch
    • Christoph Wilhelm
    News & Views
    Nature Immunology
    Volume: 27, P: 393-394

  • An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

    • Erola Pairo-Castineira
    • Konrad Rawlik
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 617, P: 764-768

  • Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

    • Athanasios Kousathanas
    • Erola Pairo-Castineira
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 607, P: 97-103

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • Filamin C is a key actin-binding protein involved in cardiomyopathies and musculoskeletal disorders. Here, Wang et al reveal that it interacts with the heat shock protein HSPB7 under biomechanical stress, forming a stable hetero-dimer which is regulated by phosphorylation.

    • Zihao Wang
    • Guodong Cao
    • Justin L. P. Benesch
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • The MAGIC investigators report results of a large genome-wide association study meta-analysis to identify common variants influencing fasting glucose homeostasis. They further show that several of the newly discovered loci influencing glycemic traits are also associated with risk of type 2 diabetes.

    • Josée Dupuis
    • Claudia Langenberg
    • Inês Barroso
    Research
    Nature Genetics
    Volume: 42, P: 105-116

  • Mucosal-associated invariant T (MAIT) cells facilitate anti-microbial responses, but their functions in cancer protection is unclear. Here the authors show that activated MAIT cells induce an IFN-γ transcriptome in natural killer (NK) cells and enhance NK-dependent anti-cancer immunity in mice, thereby hinting a new avenue for cancer therapy.

    • Emma V. Petley
    • Hui-Fern Koay
    • Phillip K. Darcy
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • A genome-wide association study of critically ill patients with COVID-19 identifies genetic signals that relate to important host antiviral defence mechanisms and mediators of inflammatory organ damage that may be targeted by repurposing drug treatments.

    • Erola Pairo-Castineira
    • Sara Clohisey
    • J. Kenneth Baillie
    Research
    Nature
    Volume: 591, P: 92-98

  • Mark McCarthy and colleagues identify twelve new risk loci for type 2 diabetes through a large-scale genome-wide association and replication study in individuals of European ancestry. The identified loci affect both beta-cell function and insulin action and are enriched for genes involved in cell cycle regulation.

    • Benjamin F Voight
    • Laura J Scott
    • Mark I McCarthy
    Research
    Nature Genetics
    Volume: 42, P: 579-589

  • The effect of sequence variants on phenotypes may depend on parental origin. Here, a method is developed that takes parental origin — the impact of which, to date, has largely been ignored — into account in genome-wide association studies. For 38,167 Icelanders genotyped, the parental origin of most alleles is determined; furthermore, a number of variants are found that show associations specific to parental origin, including three with type 2 diabetes.

    • Augustine Kong
    • Valgerdur Steinthorsdottir
    • Kari Stefansson
    Research
    Nature
    Volume: 462, P: 868-874

  • This Review describes the current state of the evidence related to therapies for oropharyngeal dysphagia — focusing on treatments most clinically utilized and of current interest to researchers.

    • Rosemary Martino
    • Timothy McCulloch
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 13, P: 665-679

  • Bioretrosynthesis is meant to simplify construction of metabolic pathways by screening only for the final desired product. This approach, aided by protein design and crystallography, is now used to synthesize an antiretroviral nucleoside analog and surprisingly identifies a new enzyme function.

    • William R Birmingham
    • Chrystal A Starbird
    • Brian O Bachmann
    Research
    Nature Chemical Biology
    Volume: 10, P: 392-399

  • This expert Consensus Statement from the Pediatric Continuous Renal Replacement Therapy (PCRRT) workgroup presents recommendations for the management of hyperammonaemia requiring kidney replacement therapy in paediatric populations. Additional studies are needed to strengthen these recommendations, which will be reviewed every 2 years.

    • Rupesh Raina
    • Jirair K. Bedoyan
    • Bradley A. Warady
    ReviewsOpen Access
    Nature Reviews Nephrology
    Volume: 16, P: 471-482