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Showing 1–2 of 2 results
Advanced filters: Author: Timothy R. Valentic Clear advanced filters

  • The antibiotic enacyloxin IIa is assembled by a modular polyketide synthase, and released from it by condensation of the enacyloxin acyl chain with 3,4-dihydroxycyclohexane carboxylic acid. A multipronged approach shows the structural basis for recognition between the peptidyl carrier protein domain that bears the acyl chain and the non-ribosomal peptide synthetase condensation domain that ligates it with the carboxylic acid.

    • Simone Kosol
    • Angelo Gallo
    • Józef R. Lewandowski
    Research
    Nature Chemistry
    Volume: 11, P: 913-923

  • Polyketides are typically assembled from a starter unit and malonyl- and/or methylmalonyl-CoA-derived extender units, but the macrolide antibiotics stambomycins incorporate non-standard alkylmalonyl-CoA extender units. Here, the authors describe the biosynthetic pathway responsible for this unusual synthesis.

    • Lauren Ray
    • Timothy R. Valentic
    • Gregory L. Challis
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12