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Showing 1–2 of 2 results
Advanced filters: Author: Tin Manh Ho Clear advanced filters
  • Na+ /H+ exchangers regulate intracellular pH, sodium levels, and cell volume. Cryo-EM structures reveal lipid coordination at the dimer interfaces of NhaA with cardiolipin and endosomal NHE9 with PI(3,5)P2. These findings demonstrate how specific lipids can regulate ion-exchange activity by stabilizing dimerization with physiological ramifications.

    • Surabhi Kokane
    • Ashutosh Gulati
    • David Drew
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17
  • GGGGCC repeat expansion in the C9orf72 gene causes amyotrophic lateral sclerosis and frontotemporal dementia. Here the authors show that CCCCGG antisense repeat RNA binds and inhibits phenylalanine-tRNA synthetase resulting in decreased levels of tRNAphe and phenylalanine rich proteins.

    • Mirjana Malnar Črnigoj
    • Urša Čerček
    • Boris Rogelj
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15