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RETRACTED ARTICLE: Polymerase θ inhibition activates the cGAS-STING pathway and cooperates with immune checkpoint blockade in models of BRCA-deficient cancer

Polymerase (POL) θ inhibitors display synthetic lethality in tumours with homologous recombination repair deficiency. Here, the authors demonstrate that POLθ inhibition with novobiocin activates the cGAS/STING pathway in BRCA-deficient cancers.

Jeffrey Patterson-Fortin
Heta Jadhav
Geoffrey I. Shapiro
ResearchOpen Access13 Mar 2023
Nature Communications

Volume: 14, P: 1-16
Post-recovery viral shedding shapes wastewater-based epidemiological inferences

Phan et al. assess the impact of prolonged viral shedding on epidemiological inferences based on wastewater data. They find that as more infected individuals recover during an outbreak, virus shed by the recovered population increases, which, if not accounted for, can lead to inaccurate epidemiological inferences.

Tin Phan
Samantha Brozak
Fuqing Wu
ResearchOpen Access22 May 2025
Communications Medicine

Volume: 5, P: 1-10
The role of magnetic resonance imaging in the preoperative evaluation of anal fistulas

Duc Vo
Chien Phan
Hung Pham
ResearchOpen Access29 Nov 2019
Scientific Reports

Volume: 9, P: 1-8
Retraction Note: Polymerase θ inhibition activates the cGAS-STING pathway and cooperates with immune checkpoint blockade in models of BRCA-deficient cancer

Jeffrey Patterson-Fortin
Heta Jadhav
Geoffrey I. Shapiro
Amendments and CorrectionsOpen Access11 Dec 2023
Nature Communications

Volume: 14, P: 1
Differences in Transcriptional Dynamics Between T-cells and Macrophages as Determined by a Three-State Mathematical Model

Catherine DeMarino
Maria Cowen
Fatah Kashanchi
ResearchOpen Access10 Feb 2020
Scientific Reports

Volume: 10, P: 1-22

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RETRACTED ARTICLE: Polymerase θ inhibition activates the cGAS-STING pathway and cooperates with immune checkpoint blockade in models of BRCA-deficient cancer

Post-recovery viral shedding shapes wastewater-based epidemiological inferences

The role of magnetic resonance imaging in the preoperative evaluation of anal fistulas

Retraction Note: Polymerase θ inhibition activates the cGAS-STING pathway and cooperates with immune checkpoint blockade in models of BRCA-deficient cancer

Differences in Transcriptional Dynamics Between T-cells and Macrophages as Determined by a Three-State Mathematical Model

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