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The Taiwan Precision Medicine Initiative provides a cohort for large-scale studies

The Taiwan Precision Medicine Initiative (TPMI) has built a cohort of more than half a million individuals with Han Chinese ancestry, providing a rich resource of genetic and medical data for this group.

Hsin-Chou Yang
Pui-Yan Kwok
Jer-Yuarn Wu
ResearchOpen Access15 Oct 2025
Nature

Volume: 648, P: 117-127
Crohn’s Disease-associated variant in laccase domain containing 1 (LACC1) modulates T cell gene expression, metabolism and T cell function

Prior studies implicate an allele near laccase domain containing 1 (LACC1) for risk of Crohn’s disease and decreased LACC1 expression in T cells. Using human genome analyzes and mouse genetic models, here the authors link specific LACC1 variants with the modulation of T cell gene expression, metabolism and function.

Yingcong Li
Gabriel Ascui
Mitchell Kronenberg
ResearchOpen Access15 Mar 2025
Nature Communications

Volume: 16, P: 1-16
Tumour suppressor death-associated protein kinase targets cytoplasmic HIF-1α for Th17 suppression

HIF-1α is critical for Th17 differentiation. Here the authors show that DAPK (Death-Associated Protein Kinase) inhibits Th17 differentiation and immunopathology in a mouse model of multiple sclerosis by promoting HIF1-α binding to its negative regulator PHD2.

Ting-Fang Chou
Ya-Ting Chuang
Ming-Zong Lai
ResearchOpen Access17 Jun 2016
Nature Communications

Volume: 7, P: 1-14
Divergent metabolic programmes control two populations of MAIT cells that protect the lung

Riffelmacher et al. show that immunization with a live vaccine strain leads to the expansion of two memory-like mucosal-associated invariant T cell lineages with distinct metabolic needs, effector programmes and protective capacities.

Thomas Riffelmacher
Mallory Paynich Murray
Mitchell Kronenberg
ResearchOpen Access25 May 2023
Nature Cell Biology

Volume: 25, P: 877-891
Deltex1 antagonizes HIF-1α and sustains the stability of regulatory T cells in vivo

Foxp3, a key transcription factor of regulatory T cells, is targeted to degradation by HIF-1α. Here the authors show that Deltex1 promotes degradation of HIF-1α, thus stabilizing Foxp3 levels and function of regulatory T cells in vivo.

Huey-Wen Hsiao
Tzu-Sheng Hsu
Ming-Zong Lai
ResearchOpen Access19 Feb 2015
Nature Communications

Volume: 6, P: 1-12
Intermittent PI3Kδ inhibition sustains anti-tumour immunity and curbs irAEs

A study using a mouse solid tumour model suggests that adjusting the dosing frequency of the PI3Kδ inhibitor AMG319 in the treatment of human cancers could decrease tumour growth with fewer adverse effects.

Simon Eschweiler
Ciro Ramírez-Suástegui
Christian H. Ottensmeier
ResearchOpen Access04 May 2022
Nature

Volume: 605, P: 741-746
SPARK Taiwan: a decade of insights in adapting US translational medicine and commercialization methods

SPARK Taiwan has strengthened the country’s biotech sector, encouraged scientists to start businesses and fostered cross-disciplinary collaboration.

Ting-Fang Lo
Yi-Chih Huang
Yufeng Jane Tseng
Comments & Opinion14 Apr 2025
Nature Biotechnology

Volume: 43, P: 647-650
Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap

Increased levels of the Yap oncoprotein stimulate liver growth and promote hepatocarcinogenesis. Here the authors show that hepatocyte-specific loss of Atg7 in mice leads to decreased autophagic degradation of Yap and liver overgrowth, and further establish this association in human liver cancer tissues.

Youngmin A. Lee
Luke A. Noon
Scott L. Friedman
ResearchOpen Access23 Nov 2018
Nature Communications

Volume: 9, P: 1-12
Tumor suppressor death-associated protein kinase 1 inhibits necroptosis by p38 MAPK activation

Yung-Hsuan Wu
Ting-Fang Chou
Ming-Zong Lai
ResearchOpen Access04 May 2020
Cell Death & Disease

Volume: 11, P: 1-15
Germ plasm localisation of the HELICc of Vasa in Drosophila: analysis of domain sufficiency and amino acids critical for localisation

Szu-Chieh Wang
Hao-Jen Hsu
Ming-Der Lin
ResearchOpen Access30 Sept 2015
Scientific Reports

Volume: 5, P: 1-16

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The Taiwan Precision Medicine Initiative provides a cohort for large-scale studies

Crohn’s Disease-associated variant in laccase domain containing 1 (LACC1) modulates T cell gene expression, metabolism and T cell function

Tumour suppressor death-associated protein kinase targets cytoplasmic HIF-1α for Th17 suppression

Divergent metabolic programmes control two populations of MAIT cells that protect the lung

Deltex1 antagonizes HIF-1α and sustains the stability of regulatory T cells in vivo

Intermittent PI3Kδ inhibition sustains anti-tumour immunity and curbs irAEs

SPARK Taiwan: a decade of insights in adapting US translational medicine and commercialization methods

Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap

Tumor suppressor death-associated protein kinase 1 inhibits necroptosis by p38 MAPK activation

Germ plasm localisation of the HELICc of Vasa in Drosophila: analysis of domain sufficiency and amino acids critical for localisation

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