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Showing 1–5 of 5 results
Advanced filters: Author: Tiongsun Chia Clear advanced filters

  • High-fidelity convergent total synthesis is used to produce Escherichia coli with a 61-codon synthetic genome that uses 59 codons to encode all of the canonical amino acids.

    • Julius Fredens
    • Kaihang Wang
    • Jason W. Chin
    Research
    Nature
    Volume: 569, P: 514-518

  • Pentatricopeptide repeat proteins bind single-stranded RNA and have been used to study ssRNA biology. Here the authors co-opt these proteins to target ssDNA and demonstrate specific binding of telomere sequences, the structural basis for ssDNA wrapping, and use them as potent telomerase inhibitors.

    • Henrik Spåhr
    • Tiongsun Chia
    • Oliver Rackham
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10

  • REXER, a new method that allows long sections of DNA to be inserted or replaced in the genome of the bacterium Escherichia coli, is used to investigate codon replacement schemes for the generation of synthetic genomes.

    • Kaihang Wang
    • Julius Fredens
    • Jason W. Chin
    Research
    Nature
    Volume: 539, P: 59-64

  • Pentatricopeptide repeat (PPR) proteins bind RNA and control diverse aspects of RNA metabolism in eukaryotic cells. Here, Coquille et al.present the crystal structures of several engineered PPR domains, elucidate their RNA binding mode and suggest paths to the design of modular, sequence-specific PPR domains.

    • Sandrine Coquille
    • Aleksandra Filipovska
    • Oliver Rackham
    Research
    Nature Communications
    Volume: 5, P: 1-9