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Control of telomere length by the human telomeric protein TRF1

Bas van Steensel
Titia de Lange
Research20 Feb 1997
Nature

Volume: 385, P: 740-743
Human telomeres contain two distinct Myb–related proteins, TRF1 and TRF2

Dominique Broccoli
Agata Smogorzewska
Titia de Lange
Research01 Oct 1997
Nature Genetics

Volume: 17, P: 231-235
Genomic environment of the expression-linked extra copies of genes for surface antigens of Trypanosoma brucei resembles the end of a chromosome

Titia De Lange
Piet Borst
Research30 Sept 1982
Nature

Volume: 299, P: 451-453
53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility

53BP1 is required for V(D)J recombination and for joining of DNA breaks in telomeres. In V(D)J recombination, the ends of the programmed double-strand break are degraded when 53BP1 is absent, and joining between distal V and DJ segments is affected. At broken telomeres, 53BP1 increases the mobility of the DNA ends in the nucleus so that they are more likely to encounter a partner to which they can be ligated. Thus, 53BP1 facilitates repair by changing the dynamics of movement of broken ends, making long-range interactions more frequent.

Nadya Dimitrova
Yi-Chun M. Chen
Titia de Lange
Research19 Oct 2008
Nature

Volume: 456, P: 524-528
Correction: Corrigendum: Telomere protection by mammalian Pot1 requires interaction with Tpp1

Dirk Hockemeyer
Wilhelm Palm
Gary D Hammer
Amendments and Corrections01 May 2009
Nature Structural & Molecular Biology

Volume: 16, P: 572
53BP1–shieldin-dependent DSB processing in BRCA1-deficient cells requires CST–Polα–primase fill-in synthesis

Mirman et al. report that the primary function of the shieldin complex in double-strand break repair in BRCA1-deficient cells is the recruitment of the CST–Polα–primase complex to conduct fill-in synthesis.

Zachary Mirman
Nanda Kumar Sasi
Titia de Lange
Research13 Jan 2022
Nature Cell Biology

Volume: 24, P: 51-61
Author Correction: Telomeres in cancer: tumour suppression and genome instability

John Maciejowski
Titia de Lange
Amendments and Corrections28 Feb 2019
Nature Reviews Molecular Cell Biology

Volume: 20, P: 259
T-loops and the origin of telomeres

Titia de Lange
Amendments and Corrections01 Jun 2004
Nature Reviews Molecular Cell Biology

Volume: 5, P: 492
CST–polymerase α-primase solves a second telomere end-replication problem

Incomplete duplication of the C-rich telomeric repeat strand by lagging-strand DNA synthesis is counteracted by DNA synthesis mediated by CST–polymerase α-primase.

Hiroyuki Takai
Valentina Aria
Titia de Lange
Research28 Feb 2024
Nature

Volume: 627, P: 664-670
Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1

At a gross level, telomere ends resemble the ends of a double-strand break caused by DNA damage, yet telomeres do not activate the DNA damage response. An insight is offered as to how this response is suppressed. Two telomere-binding proteins, TRF2 and POT1, inhibit the activities of two upstream 'sensor' damage-responsive kinases, ATM and ATR, respectively. As these kinases initiate the signalling cascades that provoke the repair of damaged DNA, their inhibition by TRF2 and POT1 makes the telomere ends 'invisible' to the DNA repair machinery.

Eros Lazzerini Denchi
Titia de Lange
Research08 Aug 2007
Nature

Volume: 448, P: 1068-1071
Telomeres in cancer: tumour suppression and genome instability

Telomere shortening and loss of telomere protection can have a tumour-suppressive effect by mediating proliferation arrest. Ultimately, however, these processes can cause a state of extensive genome instability known as telomere crisis, which can facilitate tumorigenesis by causing oncogenic chromosomal rearrangements, including chromothripsis, kataegis and tetraploidization.

John Maciejowski
Titia de Lange
Reviews18 Jan 2017
Nature Reviews Molecular Cell Biology

Volume: 18, P: 175-186
DNA-PK and the TRF2 iDDR inhibit MRN-initiated resection at leading-end telomeres

Here, the authors show that DNA-PK and TRF2, via its iDDR, suppress MRN nucleolytic processing of leading-end blunt telomeres, which are instead processed by Apollo or, in its absence, are aberrantly fused by alternative end-joining.

Logan R. Myler
Beatrice Toia
Francisca Lottersberger
ResearchOpen Access31 Aug 2023
Nature Structural & Molecular Biology

Volume: 30, P: 1346-1356
Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres

Xu-Dong Zhu
Bernhard Küster
Titia de Lange
Research01 Jul 2000
Nature Genetics

Volume: 25, P: 347-352
Ku70 stimulates fusion of dysfunctional telomeres yet protects chromosome ends from homologous recombination

Giulia B. Celli
Eros Lazzerini Denchi
Titia de Lange
Research16 Jul 2006
Nature Cell Biology

Volume: 8, P: 885-890
POT1 as a terminal transducer of TRF1 telomere length control

Diego Loayza
Titia de Lange
Research25 May 2003
Nature

Volume: 423, P: 1013-1018
DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion

Giulia B. Celli
Titia de Lange
Research19 Jun 2005
Nature Cell Biology

Volume: 7, P: 712-718
TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex

Jeffrey Zheng-Sheng Ye
Titia de Lange
Research09 May 2004
Nature Genetics

Volume: 36, P: 618-623
Protection of mammalian telomeres

Titia de Lange
Reviews11 Feb 2002
Oncogene

Volume: 21, P: 532-540
Cryo-EM structure of the human CST–Polα/primase complex in a recruitment state

Cryo-EM analysis of the human CST–Polα/primase complex reveals a metazoan-specific mode of interaction between CST and DNA polymerase α that is proposed to function in telomeric recruitment of Polα/primase for C-strand maintenance.

Sarah W. Cai
John C. Zinder
Titia de Lange
ResearchOpen Access16 May 2022
Nature Structural & Molecular Biology

Volume: 29, P: 813-819
Most large structural variants in cancer genomes can be detected without long reads

JaBbA v1 pinpoints the ‘loose ends’ of large (>10-kb) unmapped structural variants in short-read DNA sequencing, suggesting that about 90% of cancer chromosomal alterations outside centromeres are resolvable with short reads and that long reads will primarily improve calling of smaller somatic variants.

Zi-Ning Choo
Julie M. Behr
Marcin Imieliński
ResearchOpen Access09 Nov 2023
Nature Genetics

Volume: 55, P: 2139-2148
Structural variant evolution after telomere crisis

Telomere crisis has been shown to induce chromothripsis and breakage fusion bridge (BFB) cycles in vitro. Here, the authors show that telomere crisis generates a much broader spectrum of structural variations, implying that cancers without chromothripsis and BFB cycles could have emerged from telomere crisis.

Sally M. Dewhurst
Xiaotong Yao
Marcin Imieliński
ResearchOpen Access07 Apr 2021
Nature Communications

Volume: 12, P: 1-17
T-loops and the origin of telomeres

Titia de Lange
Reviews01 Apr 2004
Nature Reviews Molecular Cell Biology

Volume: 5, P: 323-329
Telomere protection by mammalian Pot1 requires interaction with Tpp1

Dirk Hockemeyer
Wilhelm Palm
Gary D Hammer
Research15 Jul 2007
Nature Structural & Molecular Biology

Volume: 14, P: 754-761
TRF2 binds branched DNA to safeguard telomere integrity

Functional analysis of TRF2-RuvC chimeras establishes that binding of the TRF2 basic domain to branched-DNA structures of the t-loop is responsible for telomere protection in mouse and human cells.

Isabelle Schmutz
Leonid Timashev
Titia de Lange
Research14 Aug 2017
Nature Structural & Molecular Biology

Volume: 24, P: 734-742
53BP1–RIF1–shieldin counteracts DSB resection through CST- and Polα-dependent fill-in

53BP1 and shieldin recruit the CTC1–STN1–TEN1 complex and polymerase-α to sites of DNA damage to help control the repair of double-strand breaks.

Zachary Mirman
Francisca Lottersberger
Titia de Lange
Research18 Jul 2018
Nature

Volume: 560, P: 112-116
Ending up with the right partner

How do the correct maternal and paternal chromosomes find one another during sexual reproduction? New data from fission yeast indicate that the search for the right partner is simplified by pre-alignment of the chromosomes through clustering of their ends.

Titia de Lange
News & Views01 Apr 1998
Nature

Volume: 392, P: 753-754
APOBEC3-dependent kataegis and TREX1-driven chromothripsis during telomere crisis

Nucleic acid processing by the cytoplasmic exonuclease TREX1 and cytosine editing by APOBEC3B drive chromothripsis and kataegis during telomere crisis.

John Maciejowski
Aikaterini Chatzipli
Titia de Lange
Research27 Jul 2020
Nature Genetics

Volume: 52, P: 884-890
Sensing the environment: lessons from fungi

All organisms use numerous signal-transduction systems to sense and respond to their environments and survive in a range of biological niches. Here, the authors review the molecular mechanisms used by the fungal kingdom to sense, and adapt in response to, diverse environmental cues.

Yong-Sun Bahn
Chaoyang Xue
Maria E Cardenas
Reviews01 Jan 2007
Nature Reviews Microbiology

Volume: 5, P: 57-69

Search

Control of telomere length by the human telomeric protein TRF1

Human telomeres contain two distinct Myb–related proteins, TRF1 and TRF2

Genomic environment of the expression-linked extra copies of genes for surface antigens of Trypanosoma brucei resembles the end of a chromosome

53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility

Correction: Corrigendum: Telomere protection by mammalian Pot1 requires interaction with Tpp1

53BP1–shieldin-dependent DSB processing in BRCA1-deficient cells requires CST–Polα–primase fill-in synthesis

Author Correction: Telomeres in cancer: tumour suppression and genome instability

T-loops and the origin of telomeres

CST–polymerase α-primase solves a second telomere end-replication problem

Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1

Telomeres in cancer: tumour suppression and genome instability

DNA-PK and the TRF2 iDDR inhibit MRN-initiated resection at leading-end telomeres

Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres

Ku70 stimulates fusion of dysfunctional telomeres yet protects chromosome ends from homologous recombination

POT1 as a terminal transducer of TRF1 telomere length control

DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion

TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex

Protection of mammalian telomeres

Cryo-EM structure of the human CST–Polα/primase complex in a recruitment state

Most large structural variants in cancer genomes can be detected without long reads

Structural variant evolution after telomere crisis

T-loops and the origin of telomeres

Telomere protection by mammalian Pot1 requires interaction with Tpp1

TRF2 binds branched DNA to safeguard telomere integrity

53BP1–RIF1–shieldin counteracts DSB resection through CST- and Polα-dependent fill-in

Ending up with the right partner

APOBEC3-dependent kataegis and TREX1-driven chromothripsis during telomere crisis

Sensing the environment: lessons from fungi

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