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Showing 1–10 of 10 results
Advanced filters: Author: Titus Franzmann Clear advanced filters

  • pH is a critical regulator of (bio)chemical processes and therefore tightly regulated in nature. Now, proteins have been shown to possess the functionality to drive pH gradients without requiring energy input or membrane enclosure but through condensation. Protein condensates can drive unique pH gradients that modulate biochemical activity in both living and artificial systems.

    • Hannes Ausserwöger
    • Rob Scrutton
    • Tuomas P. J. Knowles
    ResearchOpen Access
    Nature Chemistry
    Volume: 18, P: 246-257

  • Biomolecular phase separation arises from collective molecular interactions and is emerging as a key theme for biological function. Here the authors propose a broadly applicable method to quantify these interactions based on compositional and energetic parameters.

    • Hannes Ausserwöger
    • Ella de Csilléry
    • Tuomas P. J. Knowles
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • In stressed cells, proteins and RNA molecules cluster together to form stress granules. It emerges that the small protein modifier ubiquitin is needed to disassemble stress granules in recovering cells.

    • Titus Franzmann
    • Simon Alberti
    News & Views
    Nature
    Volume: 597, P: 183-184

  • Stress granules function at sites of intracellular membrane damage by forming on and stabilizing the ruptured membrane and promoting membrane repair.

    • Claudio Bussi
    • Agustín Mangiarotti
    • Maximiliano G. Gutierrez
    ResearchOpen Access
    Nature
    Volume: 623, P: 1062-1069

  • Physical characterisation of proteins is challenging. Here the authors report single-molecule microfluidic diffusional sizing (smMDS) to enable calibration-free single-molecule diffusional-sizing based monitoring of protein hydrodynamic radii even within heterogenous multicomponent mixtures.

    • Georg Krainer
    • Raphael P. B. Jacquat
    • Tuomas P. J. Knowles
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19

  • A central concept for characterising phase-separating systems is the phase diagram but generation of such diagrams for biomolecular systems is typically slow and low-throughput. Here the authors describe PhaseScan, a combinatorial droplet microfluidic platform for high-resolution acquisition of multidimensional biomolecular phase diagrams.

    • William E. Arter
    • Runzhang Qi
    • Tuomas P. J. Knowles
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10

  • There are limitations with current protein sensing methods. Here the authors report DigitISA, a digital immunosensor assay based on microchip electrophoretic separation and single-molecule detection that enables quantitation of protein biomarkers in a single, solution-phase step.

    • Georg Krainer
    • Kadi L. Saar
    • Tuomas P. J. Knowles
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-21

  • Elucidating the molecular driving forces underlying liquid–liquid phase separation is a key objective for understanding biological function and malfunction. Here the authors show that a wide range of cellular proteins, including FUS, TDP-43, Brd4, Sox2, and Annexin A11, which form condensates at low salt concentrations, can reenter a phase-separated regime at high salt concentrations.

    • Georg Krainer
    • Timothy J. Welsh
    • Tuomas P. J. Knowles
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14