Nature Search

The F-pilus biomechanical adaptability accelerates conjugative dissemination of antimicrobial resistance and biofilm formation

Enteropathogenic bacteria use extracellular appendages, known as F-pili, to share plasmids carrying antibiotic resistance genes. Here, the authors show that F-pili are highly flexible but robust at the same time, and this is important for plasmid transfer and formation of biofilms that protect against the action of antibiotics.

Jonasz B. Patkowski
Tobias Dahlberg
Tiago R. D. Costa
ResearchOpen Access05 Apr 2023
Nature Communications

Volume: 14, P: 1-14
Structural and functional consequences of the STAT5B^N642H driver mutation

Hyper-activated STAT5B and its disease-causing variants are of interest as cancer drug targets. Here the authors combine cell based studies, X-ray crystallography, biophysical experiments and MD simulations to structurally and functionally characterize the STAT5B^N642H mutant found in aggressive T-cell leukemia and lymphomas and find that it has an increased affinity for self-dimerization.

Elvin D. de Araujo
Fettah Erdogan
Patrick T. Gunning
ResearchOpen Access07 Jun 2019
Nature Communications

Volume: 10, P: 1-15
Archaic chaperone–usher pili self-secrete into superelastic zigzag springs

The Csu pili of the multidrug-resistant nosocomial pathogen Acinetobacter baumannii assemble into an ultrathin zigzag architecture secured by a clinch mechanism that provides the pilus with high mechanical stability and superelasticity.

Natalia Pakharukova
Henri Malmi
Anton V. Zavialov
ResearchOpen Access19 Jul 2022
Nature

Volume: 609, P: 335-340
Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

Helleday and colleagues describe a nanomolar MTHFD2 inhibitor that causes replication stress and DNA damage accumulation in cancer cells via thymidine depletion, demonstrating a potential therapeutic strategy in AML tumors in vivo.

Nadilly Bonagas
Nina M. S. Gustafsson
Thomas Helleday
ResearchOpen Access28 Feb 2022
Nature Cancer

Volume: 3, P: 156-172
Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity

Here the authors generate a capsid-like particle based vaccine candidate displaying the receptor-binding domain of the SARS-CoV-2 spike protein and show induction of neutralizing antibodies after intramuscular prime-boost immunization in mice.

Cyrielle Fougeroux
Louise Goksøyr
Adam F. Sander
ResearchOpen Access12 Jan 2021
Nature Communications

Volume: 12, P: 1-11
Detectable clonal mosaicism and its relationship to aging and cancer

Luis Pérez-Jurado, Stephen Chanock and colleagues detect clonal chromosomal abnormalities in peripheral blood or buccal samples from individuals in the general population. They show that the frequency of such events increases with age and is associated with elevated risk of developing subsequent hematological cancers.

Kevin B Jacobs
Meredith Yeager
Stephen J Chanock
Research06 May 2012
Nature Genetics

Volume: 44, P: 651-658
Temporal order of clinical and biomarker changes in familial frontotemporal dementia

Empirically based models of disease progression in familial frontotemporal dementia reveal the relative ordering of clinical, neuroimaging, and fluid biomarker changes and facilitate novel clinical trial designs

Adam M. Staffaroni
Melanie Quintana
Sónia Afonso
Research22 Sept 2022
Nature Medicine

Volume: 28, P: 2194-2206
Patient-specific sequencing panels enable sensitive circulating tumor DNA analysis in rhabdomyosarcoma independent of genetic profile

Ida Rahmqvist
Agnes Dahlstrand Rudin
Martin Dalin
ResearchOpen Access21 Oct 2025
npj Precision Oncology

Volume: 9, P: 1-10
SARS-CoV-2 evolution during treatment of chronic infection

Chronic infection with SARS-CoV-2 leads to the emergence of viral variants that show reduced susceptibility to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma.

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Research05 Feb 2021
Nature

Volume: 592, P: 277-282
Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Sera from vaccinated individuals and some monoclonal antibodies show a modest reduction in neutralizing activity against the B.1.1.7 variant of SARS-CoV-2; but the E484K substitution leads to a considerable loss of neutralizing activity.

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Research11 Mar 2021
Nature

Volume: 593, P: 136-141
Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults

Cortex morphology varies with age, cognitive function, and in neurological and psychiatric diseases. Here the authors report 160 genome-wide significant associations with thickness, surface area and volume of the total cortex and 34 cortical regions from a GWAS meta-analysis in 22,824 adults.

Edith Hofer
Gennady V. Roshchupkin
Sudha Seshadri
ResearchOpen Access22 Sept 2020
Nature Communications

Volume: 11, P: 1-16
Statistical mechanics for metabolic networks during steady state growth

Single cell growth rate variability has been difficult to understand. Here, the authors apply a generalization of flux balance analysis to single cells based on maximum entropy modeling, and find that growth rate fluctuations of E. coli reflect metabolic flux variability and growth sub-optimality, in turn highlighting information costs for growth optimization.

Daniele De Martino
Anna MC Andersson
Gašper Tkačik
ResearchOpen Access30 Jul 2018
Nature Communications

Volume: 9, P: 1-9
Reduced Intensity transplantation vs chemotherapy in CR1. A prospective, pseudorandomized study in 50–70 year old AML patients

Mats Brune
Thomas Kiss
Per Ljungman
ResearchOpen Access02 Sept 2024
Bone Marrow Transplantation

Volume: 59, P: 1676-1682
The physiology and genetics of bacterial responses to antibiotic combinations

Combining several antibiotics, either in mixtures or sequential order, is proposed to increase treatment efficacy and reduce resistance evolution. In this Review, Andersson and colleagues discuss the effects of antibiotic combinations, the directional effects of previous antibiotic treatments and the role of stress-response systems as well as the interactions between drugs and resistance mutations.

Roderich Roemhild
Tobias Bollenbach
Dan I. Andersson
Reviews03 Mar 2022
Nature Reviews Microbiology

Volume: 20, P: 478-490
Numerical evaluation of cutting strategies for thin-walled parts

Andreas Andersson Lassila
Daniel Svensson
Tobias Andersson
ResearchOpen Access17 Jan 2024
Scientific Reports

Volume: 14, P: 1-16
Correction to: Distribution of fitness effects of cross-species transformation reveals potential for fast adaptive evolution

Isabel Rathmann
Mona Förster
Berenike Maier
Amendments and CorrectionsOpen Access31 May 2023
The ISME Journal

Volume: 17, P: 1352
Profiling the heterogeneity of colorectal cancer consensus molecular subtypes using spatial transcriptomics

Alberto Valdeolivas
Bettina Amberg
Kerstin Hahn
ResearchOpen Access10 Jan 2024
npj Precision Oncology

Volume: 8, P: 1-16
Human MLL/KMT2A gene exhibits a second breakpoint cluster region for recurrent MLL–USP2 fusions

Claus Meyer
Bruno A. Lopes
Rolf Marschalek
ResearchOpen Access21 Mar 2019
Leukemia

Volume: 33, P: 2306-2340
Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia

Ida E Sønderby
Ómar Gústafsson
Ole A. Andreassen
ResearchOpen Access03 Oct 2018
Molecular Psychiatry

Volume: 25, P: 584-602
A novel approach to exploring infant gaze patterns with AI-manipulated videos

Charlotte Viktorsson
Tobias Lundman
Kim Astor
ResearchOpen Access20 Jun 2025
Scientific Reports

Volume: 15, P: 1-10
Expression profiling of small intestinal neuroendocrine tumors identifies subgroups with clinical relevance, prognostic markers and therapeutic targets

Ellinor Andersson
Yvonne Arvidsson
Ola Nilsson
Research11 Mar 2016
Modern Pathology

Volume: 29, P: 616-629
A genome-wide association meta-analysis of prognostic outcomes following cognitive behavioural therapy in individuals with anxiety and depressive disorders

Christopher Rayner
Jonathan R. I. Coleman
Thalia C. Eley
ResearchOpen Access23 May 2019
Translational Psychiatry

Volume: 9, P: 1-13
Efficacy of an Internet-based self-help intervention with human guidance or automated messages to alleviate loneliness: a three-armed randomized controlled trial

Noëmi Seewer
Andrej Skoko
Tobias Krieger
ResearchOpen Access19 Mar 2024
Scientific Reports

Volume: 14, P: 1-16
Digital RNA sequencing using unique molecular identifiers enables ultrasensitive RNA mutation analysis

Digital RNA sequencing using unique molecular identifiers and well-performing reverse transcription allows detection of mutant allele frequencies < 0.1%.

Manuel Luna Santamaría
Daniel Andersson
Anders Ståhlberg
ResearchOpen Access01 Mar 2024
Communications Biology

Volume: 7, P: 1-13
3D printed water-soluble scaffolds for rapid production of PDMS micro-fluidic flow chambers

Tobias Dahlberg
Tim Stangner
Magnus Andersson
ResearchOpen Access20 Feb 2018
Scientific Reports

Volume: 8, P: 1-10
Discovering viral genomes in human metagenomic data by predicting unknown protein families

Mauricio Barrientos-Somarribas
David N. Messina
Erik L. L. Sonnhammer
ResearchOpen Access08 Jan 2018
Scientific Reports

Volume: 8, P: 1-12
Author Correction: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Amendments and Corrections21 Jul 2022
Nature

Volume: 608, P: E24
Author Correction: SARS-CoV-2 evolution during treatment of chronic infection

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Amendments and Corrections21 Jul 2022
Nature

Volume: 608, P: E23
1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans

Ida E. Sønderby
Dennis van der Meer
Marianne B. M. van den Bree
ResearchOpen Access22 Mar 2021
Translational Psychiatry

Volume: 11, P: 1-16
Modeling of the fracture energy on the finite element simulation in Ti6Al4V alloy machining

Carolina Bermudo Gamboa
Tobias Andersson
Lorenzo Sevilla Hurtado
ResearchOpen Access16 Sept 2021
Scientific Reports

Volume: 11, P: 1-13
The ketogenic diet influences taxonomic and functional composition of the gut microbiota in children with severe epilepsy

Marie Lindefeldt
Alexander Eng
Stefanie Prast-Nielsen
ResearchOpen Access23 Jan 2019
npj Biofilms and Microbiomes

Volume: 5, P: 1-13
Distribution of fitness effects of cross-species transformation reveals potential for fast adaptive evolution

Isabel Rathmann
Mona Förster
Berenike Maier
ResearchOpen Access12 Oct 2022
The ISME Journal

Volume: 17, P: 130-139
Hepcidin discriminates sepsis from other critical illness at admission to intensive care

Jon Olinder
Alex Börjesson
Cecilia Rydén
ResearchOpen Access01 Sept 2022
Scientific Reports

Volume: 12, P: 1-16
Association between living environment and human oral viral ecology

Refugio Robles-Sikisaka
Melissa Ly
David T Pride
Research18 Apr 2013
The ISME Journal

Volume: 7, P: 1710-1724
Patient-specific brain arteries molded as a flexible phantom model using 3D printed water-soluble resin

Daniel P. G. Nilsson
Madelene Holmgren
Magnus Andersson
ResearchOpen Access17 Jun 2022
Scientific Reports

Volume: 12, P: 1-9
Female mice lacking Pald1 exhibit endothelial cell apoptosis and emphysema

Isabel Egaña
Hiroshi Kaito
Stefanie Leuchtenberger
ResearchOpen Access13 Nov 2017
Scientific Reports

Volume: 7, P: 1-13
Correction: Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia

Ida E. Sønderby
Ómar Gústafsson
Ole A. Andreassen
Amendments and Corrections31 Jan 2019
Molecular Psychiatry

Volume: 25, P: 692-695
K5/K14-positive cells contribute to salivary gland-like breast tumors with myoepithelial differentiation

Werner Boecker
Goeran Stenman
Igor Buchwalow
Research05 Apr 2013
Modern Pathology

Volume: 26, P: 1086-1100
Hypertension: sex-related differences in drug treatment, prevalence and blood pressure control in primary care

Johan-Emil Bager
Karin Manhem
Georgios Mourtzinis
ReviewsOpen Access19 Jan 2023
Journal of Human Hypertension

Volume: 37, P: 662-670

Search

Filter By:

Search

Quick links