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Showing 1–4 of 4 results
Advanced filters: Author: Tobias Benkel Clear advanced filters

  • How carvedilol, a β1-blocker, activates β2-adrenoceptors, is unclear. Here, the authors resolve this enigma and show that carvedilol drives all of its detectable cellular β2-adrenoceptor signals by slow and low efficacy G protein activation.

    • Tobias Benkel
    • Mirjam Zimmermann
    • Evi Kostenis
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-20

  • Opioids modulate pain, anxiety and stress by activating four subtypes of opioid receptors. The authors show that atypical chemokine receptor 3 (ACKR3) is a scavenger for various endogenous opioid peptides regulating their availability without activating downstream signaling.

    • Max Meyrath
    • Martyna Szpakowska
    • Andy Chevigné
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • Arrestins terminate signaling from GPCRs, but several lines of evidence suggest that they are also able to transduce signals independently of G proteins. Here, the authors systematically ablate G proteins in cell lines, and show that arrestins are unable to act as genuine signal initiators.

    • Manuel Grundmann
    • Nicole Merten
    • Evi Kostenis
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-16