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Showing 1–5 of 5 results
Advanced filters: Author: Tobias G. Schips Clear advanced filters

  • Beneficial and detrimental effects have been ascribed to the different Thrombospondin (Thbs) proteins in the adult mammalian heart. Here, the authors show that Thbs1-mediated activation of PERK-eIF2α-ATF4-induced autophagy regulates adult cardiomyocyte size in the stressed heart.

    • Davy Vanhoutte
    • Tobias G. Schips
    • Jeffery D. Molkentin
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • Little is known about the changes in mRNA splicing, processing and stability that can alter gene expression during heart failure. Here, the authors show that BEX1 is induced during heart failure and is part of a ribonucleoprotein complex enhancing the expression and stability of proinflammatory genes.

    • Federica Accornero
    • Tobias G. Schips
    • Jeffery D. Molkentin
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11

  • Thrombospondin 4 has been shown to protect the heart and the skeletal muscle by enhancing matrix secretion and membrane stability thanks to its intracellular function. Here the authors show that thrombospondin 3 exacerbates injury-induced cardiomyopathy and promotes destabilization of the cardiomyocyte membrane by impairing integrin trafficking to the sarcolemma.

    • Tobias G. Schips
    • Davy Vanhoutte
    • Jeffery D. Molkentin
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15