Search

Here the authors compare genetic testing strategies in rare movement disorders, improve diagnostic yield with genome analysis, and establish CD99L2 as an X-linked spastic ataxia gene, showing that CD99L2–CAPN1 signaling disruption likely drives neurodegeneration.

Photonic crystal microresonators permit precise control of nonlinear optical processes. By suppressing specific parasitic processes, they enable the efficient and robust generation of single-mode squeezed vacuum states of light.

Phase-stabilized frequency combs are critical for optical precision measurements. They have now been realized in a chip-scale format with CMOS compatible electrical control

Here, the authors show that the resolution and speed limitations in broadband photo-acoustic spectroscopy can be overcome by combining dual-comb spectroscopy with photo-acoustic detection. This enables broadband detection and allows for rapid and sensitive multi-species molecular analysis across all wavelengths of light.

Here the authors demonstrate ultraviolet astronomical frequency combs, derived from the near-infrared domain via efficient harmonic generation in nanophotonic waveguides, to provide precision calibration to astronomical spectrographs for exoplanet science and precision cosmology.

As a pioneer in the research on ultra-high-quality dielectric microresonators and their applications in nonlinear optics, frequency metrology and laser science, Mikhail Gorodetsky is badly missed.

Amplification of laser pulses is key for ultrafast and broadband measurements in physics, biology, and chemistry. Here, the authors show that a femtosecond pulse amplifier, providing 800 Watts of peak power, can be integrated on a photonic chip.

A microphotonic astrocomb is demonstrated via temporal dissipative Kerr solitons in photonic-chip-based silicon nitride microresonators with a precision of 25 cm s^–1 (radial velocity equivalent), useful for Earth-like planet detection and cosmological research.

A scalable solution involving direct wafer-bonding of high-quality, epitaxially grown gallium phosphide to low-index substrates is introduced. The promise of this platform for integrated nonlinear photonics is demonstrated with low-threshold frequency comb generation, frequency-doubled combs and Raman lasing.

Molecules of solitons provide insight into fundamental interactions between them and the underlying nonlinear system. The reported heteronuclear molecules, comprised of dissipative solitons with distinct frequencies, temporal widths, and energies enter the multistability regime and yield in interlocked frequency combs.

Kerr frequency combs are well suited for high-capacity data transmission with phase-sensitive modulation formats. This work demonstrates error-free transmission with data rates of up to 1.44 Tbit s⁻¹, spectral efficiencies of up to 6 bit s⁻¹ Hz⁻¹ and transmission distances of up to 300 km.

Photonic crystal microring resonators with a periodic corrugation inscribed along the resonator’s circumference allow programmable synthetic reflection for self-injection-locked microcombs and their operation exclusively in the single-soliton regime.

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

By driving a high-Q fibre-based Fabry–Pérot microresonator with periodic, picosecond optical pulses, deterministic generation of stable femtosecond dissipative cavity solitons has been experimentally realized.

A CMOS-compatible watt-class power amplifier based on large-mode waveguide technology is realized with an on-chip output power reaching ~1 W within a footprint of ~4 mm², enabling integrated photonics to tackle true systems level integration.

In this large-scale metagenomics study encompassing 3,483 human host-derived samples from seven body sites, researchers identify 583 unreported single-genome bins and report 314 metagenome-disease as well as 814 biosynthetic gene-disease associations.

A Bose–Einstein condensate is created in space that has sufficient stability to enable its characteristic dynamics to be studied.

Swarm Learning is a decentralized machine learning approach that outperforms classifiers developed at individual sites for COVID-19 and other diseases while preserving confidentiality and privacy.

An integrated high-energy laser that combines a passively Q-switched laser cavity based on a silicon-nitride photonic integrated circuit with an optically pumped gain layer consisting of thulium-doped alumina is reported, representing a pivotal advancement in integrated pulsed lasers.

Optical frequency combs are vital tools for precision measurements, and extending them further into the mid-infrared 'molecular fingerprint' range will open new avenues for spectroscopy. Using crystalline microresonators, Wang et al. demonstrate Kerr combs at 2.5 μm as a promising route into the mid-infrared.

Temporal dissipative solitons are observed in a nonlinear, high-finesse, optical microresonator driven by a continuous-wave laser. This approach enables ultrashort pulses to be generated in spectral regimes lacking broadband laser gain media and saturable absorbers, making it potentially useful for applications in broadband spectroscopy, telecommunications, astronomy and low-phase-noise microwave generation.

Based on observations in crystalline MgF₂ and planar Si₃N₄ microresonators, scientists reveal that the existence of multiple and broad-beat notes in a Kerr-frequency comb is due to the formation dynamics of the comb itself. This work identifies the conditions requires for low-phase-noise performance and also helps to elucidate a number of yet-unexplained phenomena.

This Review discusses the developments and applications of on-chip optical frequency comb generation based on two concepts—supercontinuum generation in photonic-chip waveguides and Kerr-comb generation in microresonators.

Discrete time crystals are a new state of matter emerging via spontaneous discrete translational symmetry breaking in time. The authors demonstrate that a dissipative discrete time crystal appears in an optical microcavity pumped by a phase-modulated continuous wave laser, offering a new route to study this exotic crystal phase.