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Showing 1–5 of 5 results

Advanced filters: Author: Tobias Seibt Clear advanced filters

Characterization of a patient-derived variant of GPX4 for precision therapy

Biochemical and structural characterization of a homozygous point mutation in the GPX4 gene (R152H) reveals loss of enzymatic function and resistance to degradation. Therapeutic treatments such as selective antioxidants can overcome R152H defects.

Hengrui Liu
Farhad Forouhar
Brent R. Stockwell
Research20 Dec 2021
Nature Chemical Biology

Volume: 18, P: 91-100
Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

Ferroptosis is a form of non-apoptotic cell death with unclear physiological relevance. Conrad and colleagues now report that unrestrained ferroptosis can lead to renal failure. They also identify a small molecule that limits ferroptosis in vivo.

Jose Pedro Friedmann Angeli
Manuela Schneider
Marcus Conrad
Research17 Nov 2014
Nature Cell Biology

Volume: 16, P: 1180-1191
Coexisting variants in OSTM1 and MANEAL cause a complex neurodegenerative disorder with NBIA-like brain abnormalities

Diran Herebian
Bader Alhaddad
Felix Distelmaier
Research14 Jun 2017
European Journal of Human Genetics

Volume: 25, P: 1092-1095
Diverse biological functions of vitamin K: from coagulation to ferroptosis

This Perspective provides a concise overview of the diverse functions of vitamin K in physiology and metabolism, including its recently discovered role in ferroptosis.

Eikan Mishima
Adam Wahida
Marcus Conrad
Reviews19 Jun 2023
Nature Metabolism

Volume: 5, P: 924-932
Composition and electronic structure of \({\rm SiO}_{\rm x}\)/\({\rm TiO}_{\rm y}\)/Al passivating carrier selective contacts on n-type silicon solar cells

Christoph Flathmann
Tobias Meyer
Michael Seibt
ResearchOpen Access22 Feb 2023
Scientific Reports

Volume: 13, P: 1-9