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Showing 1–5 of 5 results
Advanced filters: Author: Tobias Wunder Clear advanced filters

  • It is unclear how often genetic mosaicism of chromosome X arises. Here, the authors examine women with cancer and cancer-free controls and show that X chromosome mosaicism occurs more frequently than on autosomes, especially on the inactive X chromosome, but is not linked to non-haematologic cancer risk

    • Mitchell J. Machiela
    • Weiyin Zhou
    • Stephen J. Chanock
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-9

  • The microalgal pyrenoid has been reported to behave as a phase-separated liquid compartment. Here the authors demonstrate that the CO2-fixing enzyme Rubisco and the linker protein EPYC1 are necessary and sufficient to bring about a liquid-liquid phase separation that recapitulates the pyrenoid’s liquid-like behavior.

    • Tobias Wunder
    • Steven Le Hung Cheng
    • Oliver Mueller-Cajar
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10

  • Luis Pérez-Jurado, Stephen Chanock and colleagues detect clonal chromosomal abnormalities in peripheral blood or buccal samples from individuals in the general population. They show that the frequency of such events increases with age and is associated with elevated risk of developing subsequent hematological cancers.

    • Kevin B Jacobs
    • Meredith Yeager
    • Stephen J Chanock
    Research
    Nature Genetics
    Volume: 44, P: 651-658

  • The structural basis of the interactions between Rubisco and its intrinsically disordered linker protein provides insight into phase separation within the algal pyrenoid, an organelle responsible for around a third of global CO2 fixation.

    • Shan He
    • Hui-Ting Chou
    • Martin C. Jonikas
    Research
    Nature Plants
    Volume: 6, P: 1480-1490