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Showing 1–9 of 9 results
Advanced filters: Author: Todd S. Macfarlan Clear advanced filters

  • KRAB-zinc finger proteins repress retrotransposons and rapidly evolve in mammals. Here, the authors show that ERV insertions drive the emergence and diversification of new KZFP genes in mice, revealing a co-evolutionary mechanism between retroviruses and host repressors.

    • Melania Bruno
    • Sharaf M. Farhana
    • Todd S. Macfarlan
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • In this Review, Senft and Macfarlan discuss the diverse ways by which transposable elements (TEs) contribute to mammalian development and evolution, including direct contributions through TE-derived regulatory elements, RNAs and proteins, as well as indirect effects through the evolution of a TE repression system, the Krüppel-associated box zinc finger proteins (KRAB-ZFPs).

    • Anna D. Senft
    • Todd S. Macfarlan
    Reviews
    Nature Reviews Genetics
    Volume: 22, P: 691-711

  • In general, the kinetochore position and the sister-chromatid cohesion site are spatially linked. Here, the authors find a meiosis-specific distal cohesion site decoupled from the kinetochore in Peromyscus mice, breaking the dogma.

    • Bo Pan
    • Melania Bruno
    • Takashi Akera
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Here the authors show that, in the absence of Pi3K–AKT–mTOR signaling, AGO2 accumulates in the nucleus of quiescent cells, where it binds to young retrotransposons and represses their expression.

    • Laura Sala
    • Manish Kumar
    • Joana A. Vidigal
    Research
    Nature Structural & Molecular Biology
    Volume: 30, P: 1985-1995

  • Strand-specific RNA-seq (ssRNA-seq) data often lack information on 5′ and 3′ ends of transcripts. Here the authors present a novel method for ssRNA-seq that enables the simultaneous profiling of gene expression, TSSs and polyadenylation sites at near-base resolution with a single library.

    • Saurabh Agarwal
    • Todd S. Macfarlan
    • Shigeki Iwase
    Research
    Nature Communications
    Volume: 6, P: 1-12

  • A rare cell subpopulation within mouse embryonic stem cell cultures is identified that exhibits properties of two-cell (2C) embryos; the interconversion of ES cells to 2C cells correlates with endogenous retroviral activity.

    • Todd S. Macfarlan
    • Wesley D. Gifford
    • Samuel L. Pfaff
    Research
    Nature
    Volume: 487, P: 57-63

  • The authors show that the neuron-specific LSD1 variant (LSD1n) promotes transcription initiation and elongation in response to neuronal activity. LSD1n is essential for spatial learning and long-term memory formation. LSD1n exhibits novel substrate specificity for histone H4 K20 methylation.

    • Jianxun Wang
    • Francesca Telese
    • Michael G Rosenfeld
    Research
    Nature Neuroscience
    Volume: 18, P: 1256-1264