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Showing 1–2 of 2 results
Advanced filters: Author: Tokio Matsuzaki Clear advanced filters

  • Osteoarthritis is caused by an imbalance between extracellular matrix synthesis and degradation. Here, the authors show that both strands of microRNA-455, -5p and -3p, target HIF2α and regulate cartilage homeostasis, and show that overexpression of these miRNAs is protective against osteoarthritis in mice.

    • Yoshiaki Ito
    • Tokio Matsuzaki
    • Hiroshi Asahara
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • Wwp2 is an HECT-type E3 ubiquitin ligase abundantly expressed in articular cartilage. Here, the authors show that in mice, loss of Wwp2 leads to upregulated Runx2-Adamts5 signaling in articular cartilage and development of osteoarthritis, and that disease severity is reduced by injection of Wwp2 mRNA

    • Sho Mokuda
    • Ryo Nakamichi
    • Hiroshi Asahara
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13