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Showing 1–4 of 4 results
Advanced filters: Author: Tom Dendooven Clear advanced filters

  • Using cryo-electron tomography, Dendooven et al. determined the structure of the native budding yeast γ-tubulin ring complex (γTuRC) capping spindle microtubules and showed that γTuRC adopts an active closed conformation to function as a perfect geometric template for microtubule nucleation.

    • Tom Dendooven
    • Stanislau Yatskevich
    • David Barford
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 31, P: 1134-1144

  • Cryo-electron microscopy structures of DNA-dependent protein kinase catalytic subunit bound to ATPγS and four inhibitors (wortmannin, NU7441, AZD7648 and M3814) provide molecular details and insights useful for drug design.

    • Shikang Liang
    • Sherine E. Thomas
    • Tom L. Blundell
    ResearchOpen Access
    Nature
    Volume: 601, P: 643-648

  • A conserved mechanism for the regulation of replisome disassembly in eukaryotes is shown using cryo-electron microscopy, revealing a role for DNA in the preservation of replisome integrity.

    • Michael Jenkyn-Bedford
    • Morgan L. Jones
    • Tom D. Deegan
    ResearchOpen Access
    Nature
    Volume: 600, P: 743-747