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Showing 1–3 of 3 results
Advanced filters: Author: Tomas Pascoa Clear advanced filters

  • Pascoa et al. reveal structures of the human ceramide synthase 6 and elucidate the enzyme’s mechanism. Furthermore, the work uncovers the basis of inhibition by the mycotoxin fumonisin B1.

    • Tomas C. Pascoa
    • Ashley C. W. Pike
    • David B. Sauer
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 32, P: 431-440

  • Here, the authors present the cryoEM structure of the sodium-translocating methyltransferase (Mtr) complex from Methanosarcina mazei. Along with providing catalytic insights, they identify MtrI, an unannotated small protein, bound to the Mtr complex in a redox-dependent manner.

    • Tristan Reif-Trauttmansdorff
    • Eva Herdering
    • Jan M. Schuller
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-14

  • ELOVLs are membrane-embedded enzymes that elongate very long chain fatty acids, precursors of sphingolipids and ceramides. The first crystal structure of a human ELOVL reveals an unexpected reaction mechanism, suggesting potential approaches for inhibition in disease.

    • Laiyin Nie
    • Tomas C. Pascoa
    • Elisabeth P. Carpenter
    Research
    Nature Structural & Molecular Biology
    Volume: 28, P: 512-520