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Showing 1–4 of 4 results
Advanced filters: Author: Tomasz Jetka Clear advanced filters

  • This Resource presents the genetic subset of the 136,000 chemical and genetic perturbations tested by the Joint Undertaking for Morphological Profiling (JUMP) Cell Painting Consortium and associated analysis of phenotypic profiles.

    • Srinivas Niranj Chandrasekaran
    • Eric Alix
    • Anne E. Carpenter
    Research
    Nature Methods
    Volume: 22, P: 1742-1752

  • Signalling responses are marked by substantial cell-to-cell variability. Here, the authors propose an information theoretic framework that accounts for multiple inputs and temporal dynamics to analyse how signals flow through shared network components.

    • Tomasz Jetka
    • Karol Nienałtowski
    • Michał Komorowski
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-9

  • Billing et al. clarify mechanisms ensuring reliable cytokine signaling despite variable expression and activation of signaling proteins in cells. Limited activation of signaling proteins either by feedback inhibition or low cytokine doses, and STAT3 serine phosphorylation timely orchestrate robustness and capacity of IL-6-induced signaling.

    • Ulrike Billing
    • Tomasz Jetka
    • Anna Dittrich
    ResearchOpen Access
    Communications Biology
    Volume: 2, P: 1-14