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Showing 1–12 of 12 results
Advanced filters: Author: Tomek Swigut Clear advanced filters

  • One of four papers establishing certain PHD domains as effectors of trimethylated histone H3K4, a chromatin mark generally associated with active transcription. This paper shows that the interaction of H3K4me3 with the PHD finger of an ATP-dependent chromatin remodelling complex is involved in control of Hox gene expression during Xenopus development.

    • Joanna Wysocka
    • Tomek Swigut
    • C. David Allis
    Research
    Nature
    Volume: 442, P: 86-90

  • A multivariate genome-wide association study identifies 203 signals associated with facial variation. These signals are enriched for enhancer activity in cranial neural crest cells and craniofacial tissues.

    • Julie D. White
    • Karlijne Indencleef
    • Peter Claes
    Research
    Nature Genetics
    Volume: 53, P: 45-53

  • The authors report a data-driven approach to phenotyping 3D facial shape. They apply their methodology to 2,329 individuals of European ancestry and identify 38 loci that associate with specific facial morphologies, some of which overlap with neural-crest-specific regulatory regions.

    • Peter Claes
    • Jasmien Roosenboom
    • Seth M. Weinberg
    Research
    Nature Genetics
    Volume: 50, P: 414-423

  • Super-enhancers (SEs) are big DNA regions regulating the transcription of oncogenes. Here the authors identify two SE regions regulating the expression of CD47, a protein expressed by cancer cells to avoid phagocytosis by macrophages, thus suggesting a potential mechanism of immune surveillance escape.

    • Paola A. Betancur
    • Brian J. Abraham
    • Irving L. Weissman
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-14

  • Prdm14 is expressed in embryonic stem (ES) cells and germ cells. It is now shown that this transcription factor safeguards the stem cell state by preventing development of mouse ES cells into extraembryonic endoderm cells by repressing loci related to differentiation along this developmental pathway. This suggests that Pdrm14 is part of the network of factors that maintains the ES cell state in mice.

    • Ziyang Ma
    • Tomek Swigut
    • Joanna Wysocka
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 120-127

  • Heterozygous mutations in the gene encoding CHD7, an ATP-dependent chromatin-remodelling protein, result in CHARGE syndrome — a disorder characterized by malformations of the craniofacial structures, peripheral nervous system, ears, eyes and heart. In humans and Xenopus, CHD7 is now shown to be essential for the formation of multipotent migratory neural crest and for activating the transcriptional circuitry of the neural crest; shedding light on the pathoembryology of CHARGE syndrome.

    • Ruchi Bajpai
    • Denise A. Chen
    • Joanna Wysocka
    Research
    Nature
    Volume: 463, P: 958-962

  • Trithorax group (trxG) and Polycomb group (PcG) gene products are part of a chromatin remodelling system that activates or silences gene expression, respectively. This paper shows that show that Mll1 (mixed-lineage leukemia 1), a trxG member, is required for neurogenesis in the postnatal brain. They show that, in Mll1-deficient cells, expression of proneural and gliogenic regulatory genes are preserved, but Dlx2, a key downstream regulator of subventricular zone neurogenesis, is not expressed.

    • Daniel A. Lim
    • Yin-Cheng Huang
    • Arturo Alvarez-Buylla
    Research
    Nature
    Volume: 458, P: 529-533

  • Identifying the genomic regulatory sequences, such as enhancers, that control early embryonic development remains a difficult challenge. Here, profiling of histone modifications and chromatin regulators in human embryonic stem cells (hESCs) reveals unique signatures that are used to identify over 2,000 putative enhancers. These enhancers are either active in the h ESCs or associated with early developmental genes.

    • Alvaro Rada-Iglesias
    • Ruchi Bajpai
    • Joanna Wysocka
    Research
    Nature
    Volume: 470, P: 279-283

  • Mutations associated with Treacher Collins syndrome perturb the subnuclear localization of an RNA helicase involved in ribosome biogenesis through activation of p53 protein, illustrating how disruption in general regulators that compromise nucleolar homeostasis can result in tissue-selective malformations.

    • Eliezer Calo
    • Bo Gu
    • Joanna Wysocka
    Research
    Nature
    Volume: 554, P: 112-117