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Octyl itaconate enhances VSVΔ51 oncolytic virotherapy by multitarget inhibition of antiviral and inflammatory pathways

The use of oncolytic viruses as a therapy for cancer is limited by mechanisms inhibiting viral replication in the tumor. Here, the authors show that a chemical derivative of itaconate, 4-octyl itaconate, increases oncolytic virus VSVΔ51 efficacy in various cancer models, through decreasing antiviral immunity.

Naziia Kurmasheva
Aida Said
David Olagnier
ResearchOpen Access15 May 2024
Nature Communications

Volume: 15, P: 1-28
Correction: Publisher Correction: Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma

Shawn T. Beug
Caroline E. Beauregard
Robert G. Korneluk
Amendments and CorrectionsOpen Access18 Jul 2018
Nature Communications

Volume: 9, P: 1
Author Correction: Octyl itaconate enhances VSVΔ51 oncolytic virotherapy by multitarget inhibition of antiviral and inflammatory pathways

Naziia Kurmasheva
Aida Said
David Olagnier
Amendments and CorrectionsOpen Access19 Dec 2024
Nature Communications

Volume: 15, P: 1
Antibiotic-mediated selection of randomly mutagenized and cytokine-expressing oncolytic viruses

The preferential susceptibility of oncolytic viruses to certain antibiotics can be exploited to accelerate the engineering of oncolytic viruses expressing transgenes for immunomodulatory cytokines.

Reza Rezaei
Stephen Boulton
Taha Azad
Research28 Nov 2024
Nature Biomedical Engineering

Volume: 9, P: 822-835
Oral reovirus reshapes the gut microbiome and enhances antitumor immunity in colon cancer

Here, the authors show that oral administration of an oncolytic reovirus (RC402) elicits robust suppression of multifocal tumor lesions and antitumor immunity through extensive rewiring of the host immunity and the gut microbiome.

Won Suk Lee
Seung Joon Lee
Chan Kim
ResearchOpen Access22 Oct 2024
Nature Communications

Volume: 15, P: 1-15
Synthetic virology approaches to improve the safety and efficacy of oncolytic virus therapies

The large coding potential of vaccinia virus (VV) vectors is a defining feature. Here the authors present vaccinia virus vector-adapted chemogenetic switches enabling temporal and dose control of viral replication and transgene expression, implementation of complex tunable transgene circuitry, and generation of safer, more efficacious vectors.

Taha Azad
Reza Rezaei
John C. Bell
ResearchOpen Access26 May 2023
Nature Communications

Volume: 14, P: 1-18
Genomic investigations of unexplained acute hepatitis in children

An investigation using various methods reports an association between adeno-associated virus 2 and paediatric hepatitis of unknown aetiology.

Sofia Morfopoulou
Sarah Buddle
Judith Breuer
ResearchOpen Access30 Mar 2023
Nature

Volume: 617, P: 564-573
Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma

Smac mimetics sensitize cancer cells to the extrinsic cell death pathway and stimulate anti-tumour immunity. In this study, the authors show that Smac mimetics can synergize with immune checkpoint inhibitors to control tumour growth in mouse cancer models, including aggressive CNS tumours, in a cytotoxic CD8⁺T-cell- and TNFα-dependent manner.

Shawn T. Beug
Caroline E. Beauregard
Robert G. Korneluk
ResearchOpen Access15 Feb 2017
Nature Communications

Volume: 8, P: 1-15
SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

Viral infections usually cause disease through direct cytopathogenic effects and excessive inflammatory responses. Here, Olagnier et al. show that two NRF2 agonists, 4-OI and DMF, possess broad IFN-independent antiviral activity and decrease host inflammatory response to SARS-CoV-2 infection.

David Olagnier
Ensieh Farahani
Christian K. Holm
ResearchOpen Access02 Oct 2020
Nature Communications

Volume: 11, P: 1-12
Translational control of the activation of transcription factor NF-κB and production of type I interferon by phosphorylation of the translation factor eIF4E

The eukaryotic translation-initiation factor eIF4E is a rate-limiting factor in protein translation. Sonenberg and colleagues show that phosphorylation of eIF4E modulates the antiviral response by selectively stimulating translation of the NF-κB inhibitor IκBα

Barbara Herdy
Maritza Jaramillo
Nahum Sonenberg
Research29 Apr 2012
Nature Immunology

Volume: 13, P: 543-550
Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3

The eIF4E-binding proteins (4E-BPs) are critical repressors of cap-dependent translation via mTOR, a pathway frequently hyperactivated in cancer. Here the authors show that 4E-BP3 specifically mediates the cap-dependent translation repression and antiproliferative effects of prolonged pharmacological mTOR inhibition.

Yoshinori Tsukumo
Tommy Alain
Nahum Sonenberg
ResearchOpen Access20 Jun 2016
Nature Communications

Volume: 7, P: 1-13
Microtubule disruption synergizes with oncolytic virotherapy by inhibiting interferon translation and potentiating bystander killing

Microtubule-destabilizing drugs and oncolytic viruses are two unrelated approaches to battle cancer. Here the authors show that microtubule-destabilizing drugs potentiate the efficiency of oncolytic rhabdoviruses by altering the cytokine production and response of the tumour cells.

Rozanne Arulanandam
Cory Batenchuk
Jean-Simon Diallo
Research30 Mar 2015
Nature Communications

Volume: 6, P: 1-14
Vascular and blood-brain barrier-related changes underlie stress responses and resilience in female mice and depression in human tissue

The vascular, cellular and molecular changes underlying sex differences in mood disorders are unclear. Here, the authors show that blood-brain barrier dysfunction modulates anxiety- and depressive-like behaviors in female mice and endothelium-specific changes associated with maladaptive responses compared to resilience to stress.

Laurence Dion-Albert
Alice Cadoret
Caroline Menard
ResearchOpen Access10 Jan 2022
Nature Communications

Volume: 13, P: 1-18
Author Correction: SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

David Olagnier
Ensieh Farahani
Christian K. Holm
Amendments and CorrectionsOpen Access21 Oct 2020
Nature Communications

Volume: 11, P: 1
S6K-STING interaction regulates cytosolic DNA–mediated activation of the transcription factor IRF3

Activation of the transcription factor IRF3 is a key event in antiviral responses. Lichty and colleagues show that recruitment of the mTOR downstream effector S6K1 to the STING-TBK1 signaling complex is required for the activation of IRF3 after infection with DNA viruses.

Fuan Wang
Tommy Alain
Brian D Lichty
Research04 Apr 2016
Nature Immunology

Volume: 17, P: 514-522
Astrocytes and the tumor microenvironment inflammatory state dictate the killing of glioblastoma cells by Smac mimetic compounds

Kyle Malone
Melanie Dugas
Shawn T. Beug
ResearchOpen Access15 Aug 2024
Cell Death & Disease

Volume: 15, P: 1-13
Loss of Dnajc21 leads to cytopenia and altered nucleotide metabolism in zebrafish

Sarada Ketharnathan
Sujata Pokharel
Jason N. Berman
ResearchOpen Access13 Aug 2024
Leukemia

Volume: 38, P: 2115-2126
Foxo3a tempers excessive glutaminolysis in activated T cells to prevent fatal gut inflammation in the murine IL-10^−/− model of colitis

Stephanie Hajjar
Nayanan Nathan
Subash Sad
Research29 Sept 2021
Cell Death & Differentiation

Volume: 29, P: 585-599
Transcriptional profiling of macrophages reveals distinct parasite stage-driven signatures during early infection by Leishmania donovani

Visnu Chaparro
Tyson E. Graber
Maritza Jaramillo
ResearchOpen Access16 Apr 2022
Scientific Reports

Volume: 12, P: 1-13
Quercetin induces pannexin 1 expression via an alternative transcript with a translationally active 5′ leader in rhabdomyosarcoma

Xiao Xiang
Huy-Dung Hoang
Kyle N. Cowan
ResearchOpen Access22 Feb 2022
Oncogenesis

Volume: 11, P: 1-15
Identification of pannexin 1-regulated genes, interactome, and pathways in rhabdomyosarcoma and its tumor inhibitory interaction with AHNAK

Xiao Xiang
Stéphanie Langlois
Kyle N. Cowan
ResearchOpen Access09 Feb 2021
Oncogene

Volume: 40, P: 1868-1883
A triple-drug nanotherapy to target breast cancer cells, cancer stem cells, and tumor vasculature

Sara El-Sahli
Khang Hua
Suresh Gadde
ResearchOpen Access04 Jan 2021
Cell Death & Disease

Volume: 12, P: 1-10

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Octyl itaconate enhances VSVΔ51 oncolytic virotherapy by multitarget inhibition of antiviral and inflammatory pathways

Correction: Publisher Correction: Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma

Author Correction: Octyl itaconate enhances VSVΔ51 oncolytic virotherapy by multitarget inhibition of antiviral and inflammatory pathways

Antibiotic-mediated selection of randomly mutagenized and cytokine-expressing oncolytic viruses

Oral reovirus reshapes the gut microbiome and enhances antitumor immunity in colon cancer

Synthetic virology approaches to improve the safety and efficacy of oncolytic virus therapies

Genomic investigations of unexplained acute hepatitis in children

Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma

SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

Translational control of the activation of transcription factor NF-κB and production of type I interferon by phosphorylation of the translation factor eIF4E

Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3

Microtubule disruption synergizes with oncolytic virotherapy by inhibiting interferon translation and potentiating bystander killing

Vascular and blood-brain barrier-related changes underlie stress responses and resilience in female mice and depression in human tissue

Author Correction: SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

S6K-STING interaction regulates cytosolic DNA–mediated activation of the transcription factor IRF3

Astrocytes and the tumor microenvironment inflammatory state dictate the killing of glioblastoma cells by Smac mimetic compounds

Loss of Dnajc21 leads to cytopenia and altered nucleotide metabolism in zebrafish

Foxo3a tempers excessive glutaminolysis in activated T cells to prevent fatal gut inflammation in the murine IL-10^−/− model of colitis

Transcriptional profiling of macrophages reveals distinct parasite stage-driven signatures during early infection by Leishmania donovani

Quercetin induces pannexin 1 expression via an alternative transcript with a translationally active 5′ leader in rhabdomyosarcoma

Identification of pannexin 1-regulated genes, interactome, and pathways in rhabdomyosarcoma and its tumor inhibitory interaction with AHNAK

A triple-drug nanotherapy to target breast cancer cells, cancer stem cells, and tumor vasculature

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