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Showing 1–14 of 14 results
Advanced filters: Author: Tommy Tsan-Yuk Lam Clear advanced filters

  • SARS-CoV-2-related coronaviruses are identified in Malayan pangolins (Manis javanica); these pangolin-associated coronaviruses belonged to two sub-lineages of SARS-CoV-2-related coronaviruses, including one that exhibits strong similarity in the receptor-binding domain to SARS-CoV-2.

    • Tommy Tsan-Yuk Lam
    • Na Jia
    • Wu-Chun Cao
    Research
    Nature
    Volume: 583, P: 282-285

  • Influenza surveillance over 15 cities across 5 provinces in China from October 2013 to July 2014 shows that the virus has diverged into distinct clades, becoming established in chickens and also disseminating to wider geographic regions.

    • Tommy Tsan-Yuk Lam
    • Boping Zhou
    • Huachen Zhu
    Research
    Nature
    Volume: 522, P: 102-105

  • Evolutionary analyses show that H7 influenza viruses probably transferred from ducks to chickens in China on at least two independent occasions, and that reassortment with H9N2 viruses generated the H7N9 outbreak lineage that recently emerged in humans in China, and a related previously unrecognized H7N7 lineage; these H7N7 viruses are shown to have the ability to infect ferrets, and the current pandemic threat could extend beyond H7N9 viruses.

    • Tommy Tsan-Yuk Lam
    • Jia Wang
    • Yi Guan
    Research
    Nature
    Volume: 502, P: 241-244

  • ARF4 GTPase activity is needed for vesicular trafficking for multiple RNA viruses. Blocking ARF4 using specific peptides redirects viral progeny to lysosomal degradation and decreases influenza and Zika virus infection in mice.

    • Ming-Yuan Li
    • Kao Deng
    • Cheng-Feng Qin
    Research
    Nature Microbiology
    Volume: 10, P: 710-723

  • Here, a draft sequence of the giant panda genome is assembled using next-generation sequencing technology alone. Genome analysis reveals a low divergence rate in comparison with dog and human genomes and insights into panda-specific traits; for example, the giant panda's bamboo diet may be more dependent on its gut microbiome than its own genetic composition.

    • Ruiqiang Li
    • Wei Fan
    • Jun Wang
    ResearchOpen Access
    Nature
    Volume: 463, P: 311-317

  • Antimicrobial resistance has evolved over decades due to widespread antimicrobial use, with resistance genes now circulating across humans, animals and the environment, creating complex cross-sector connectivity challenges. This Perspective advocates for genomics-based studies of AMR connectivity to enable coordinated global action and investment under the One Health framework.

    • Liguan Li
    • Bing Li
    • Tong Zhang
    Reviews
    Nature Water
    Volume: 3, P: 1100-1113

  • In this manuscript, the authors address evolutionary questions on the emergence of SARS-CoV-2. They find that SARS-CoV-2 is not a recombinant of any sarbecoviruses detected to date, and that the bat and pangolin sequences most closely related to SARS-CoV-2 probably diverged several decades ago or possibly earlier from human SARS-CoV-2 samples.

    • Maciej F. Boni
    • Philippe Lemey
    • David L. Robertson
    Research
    Nature Microbiology
    Volume: 5, P: 1408-1417

  • During the COVID-19 pandemic, genomics and bioinformatics have emerged as essential public health tools. The genomic data acquired using these methods have supported the global health response, facilitated the development of testing methods and allowed the timely tracking of novel SARS-CoV-2 variants. Yet the virtually unlimited potential for rapid generation and analysis of genomic data is also coupled with unique technical, scientific and organizational challenges. Here, we discuss the application of genomic and computational methods for efficient data-driven COVID-19 response, the advantages of the democratization of viral sequencing around the world and the challenges associated with viral genome data collection and processing.

    • Sergey Knyazev
    • Karishma Chhugani
    • Serghei Mangul
    Comments & Opinion
    Nature Methods
    Volume: 19, P: 374-380