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Showing 1–2 of 2 results
Advanced filters: Author: Tomoko Isosaka Clear advanced filters

  • Matsuo, Isosaka, et al report that innate fear, but not learned fear, in mice results in systemic hypothermia/hypometabolism and suppressed aerobic metabolism, which enables survival in hypoxic environments. They demonstrate that this process is orchestrated via the brain stem Sp5/NST to midbrain PBN pathway. This study provides insight into the relationship between innate fear and its intrinsic life protective abilities

    • Tomohiko Matsuo
    • Tomoko Isosaka
    • Ko Kobayakawa
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-17

  • Matsuo et al. report that thiazoline-related innate fear-eliciting compounds activate the spinal trigeminal nucleus (Sp5) and the nucleus of the solitary tract (NTS) via vagal/trigeminal TRPA1 to induce robust physiological alterations, enabling long time survival in a lethal hypoxic environment.

    • Tomohiko Matsuo
    • Tomoko Isosaka
    • Ko Kobayakawa
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17