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Showing 1–5 of 5 results
Advanced filters: Author: Tomonari Hayama Clear advanced filters

  • CRISPR–Cas9 genome editing is used to induce a DNA repair response and correct a disease-causing heterozygous mutation in human embryos with reduced mosaicism and preferential repair using the wild-type copy of the gene.

    • Hong Ma
    • Nuria Marti-Gutierrez
    • Shoukhrat Mitalipov
    Research
    Nature
    Volume: 548, P: 413-419

    • Hong Ma
    • Nuria Marti-Gutierrez
    • Shoukhrat Mitalipov
    Research
    Nature
    Volume: 560, P: E10-E23

  • Analysis of mitochondrial replacement therapy shows, even with efficient mutant mitochondrial DNA replacement and maintenance in embryonic stem cells, a gradual loss of donor mitochondrial DNA in some lines owing to a polymorphism in the D-loop, potentially causing preferential replication of specific mitochondrial DNA haplotypes.

    • Eunju Kang
    • Jun Wu
    • Shoukhrat Mitalipov
    Research
    Nature
    Volume: 540, P: 270-275

  • Mutations in mitochondrial (mt)DNA are associated with severe disorders for which treatment is currently limited; this study shows that mtDNA mutations can be genetically corrected and normal metabolic function restored in cells derived from patients with mtDNA disease and reprogrammed to pluripotency through factor-mediated reprogramming or via a somatic cell nuclear transfer approach.

    • Hong Ma
    • Clifford D. L. Folmes
    • Shoukhrat Mitalipov
    Research
    Nature
    Volume: 524, P: 234-238