Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–11 of 11 results
Advanced filters: Author: Tomoya Kujirai Clear advanced filters

  • CRISPR-Cas9 derived from prokaryotes is a powerful genome editing tool. Here, authors report cryo-EM structure of Cas9-sgRNA-nucleosome complex targeting linker DNA, providing insights into Cas9’s interaction with nucleosomes and its implications for genome editing in chromatin.

    • Reina Nagamura
    • Tomoya Kujirai
    • Osamu Nureki
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-10

  • Here the authors reveal that oncoprotein DEK binds the nucleosome, colocalizes with H3 K27 trimethylation and stimulates Polycomb repressive complex 2 methyltransferase through chromatin compaction, as revealed by the cryo-electron microscopy structures of nucleosome-bound DEK.

    • Tomoya Kujirai
    • Kenta Echigoya
    • Hitoshi Kurumizaka
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 32, P: 1183-1192

  • Here, the authors develop a cell-permeable chemical catalyst that acetylates histone H2BK120 in leukemia cells, attenuates NELFE chromatin binding, reprograms transcription, and reduces the tumorigenic potential of leukemia cells in mice.

    • Yuki Yamanashi
    • Shinpei Takamaru
    • Motomu Kanai
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Chemical catalysts that can promote physiologically important post-translational modifications acting as enzyme surrogates have not been reported. Here, the authors develop mBnA, a chemical catalyst that promotes histone lysine acylation in live cells by activating endogenous acyl-CoAs as the only acyl donors.

    • Misuzu Habazaki
    • Shinsuke Mizumoto
    • Motomu Kanai
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-12

  • High-mobility group AT-hook (HMGA) proteins 1 and 2 are nonhistone chromatin proteins involved in different biological processes. Here the authors reveal that HMGA2 is a bona fide chromatin condensation factor that undergoes liquid–liquid phase separation, and that its chromatin condensation activity is important for the maintenance of mouse neural progenitor cells.

    • Naohiro Kuwayama
    • Tomoya Kujirai
    • Yukiko Gotoh
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18

  • Research combining molecular dynamics simulations and solid-state nanopore measurements reveals distinct disassembly pathways that may explain the distinct properties and roles of H2A.B nucleosomes in spermatogenesis, embryogenesis, and oncogenesis.

    • Hikaru Nozawa
    • Fritz Nagae
    • Sotaro Uemura
    ResearchOpen Access
    Communications Biology
    Volume: 7, P: 1-9

  • Hirano et al. show that the H2A.B-H2B histone dimer incorporated within the nucleosome exchanges with the canonical H2A-H2B dimer without assistance from histone chaperones or nucleosome remodelers. This study provides insights into how the H2A.B nucleosome exchanges its histones.

    • Rina Hirano
    • Yasuhiro Arimura
    • Hitoshi Kurumizaka
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-11

  • Ken Morishima et al. integrate small-angle scattering (SAS) with analytical-ultracentrifugation (AUC) to analyze the scattering intensity of biomacromolecules in solution. Their new approach allows to correct for the aggregation effect and can be applied to multi-component systems.

    • Ken Morishima
    • Aya Okuda
    • Masaaki Sugiyama
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-7