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Showing 1–2 of 2 results
Advanced filters: Author: Toni Ingolf Gossmann Clear advanced filters

  • By combining structural biology and evolutionary genomics analyses, the evolution of enzymes over 400 million years is shown to be governed by catalytic function, metabolic network architecture, cost and molecular interactions.

    • Oliver Lemke
    • Benjamin Murray Heineike
    • Markus Ralser
    ResearchOpen Access
    Nature
    Volume: 644, P: 280-289

  • Since protein interactions can be sensitive to small sequence changes, phylogenomics alone gives limited insight into protein functional evolution. Here, the authors illustrate how the combination of phylogenomics and interaction proteomics helps elucidate protein functional evolution with a study of the shelterin complex evolution.

    • Dennis Kappei
    • Marion Scheibe
    • Falk Butter
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-9