Type 1 polyketides are a major class of natural products with diverse bioactivities but are mostly identified via bioactivity-guided purification which is limited to relatively abundant compounds. Here, the authors present Seq2PKS, a machine learning algorithm that predicts the chemical structures derived from Type 1 polyketide synthases and use it to discover biosynthetic gene clusters for monazomycin, oasomycin A, and 2-aminobenzamideactiphenol.
- Donghui Yan
- Muqing Zhou
- Hosein Mohimani
