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Showing 1–50 of 78 results

Advanced filters: Author: Toshiaki Shimizu Clear advanced filters

Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence

Masaharu Noda
Shin Shimizu
Shosaku Numa
Research08 Nov 1984
Nature

Volume: 312, P: 121-127
Kinetics of lymphocyte stimulation by concanavalin A

SATOSHI TOYOSHIMA
MAKOTO IWATA
TOSHIAKI OSAWA
Research02 Dec 1976
Nature

Volume: 264, P: 447-449
Cloning, sequencing and expression of cDNA for a novel subunit of acetylcholine receptor from calf muscle

Toshiyuki Takai
Masaharu Noda
Shosaku Numa
Research01 Jun 1985
Nature

Volume: 315, P: 761-764
Low friction layer in sanitary products for reduced skin irritation

Toshiaki Nishi
Kenta Matsui
Takeshi Yamaguchi
ResearchOpen Access29 Sept 2025
Scientific Reports

Volume: 15, P: 1-10
De novo annotation reveals transcriptomic complexity across the hexaploid wheat pan-genome

Available wheat genomes are annotated by projecting Chinese Spring gene models across the new assemblies. Here, the authors generate de novo gene annotations for the 9 wheat genomes, identify core and dispensable transcriptome, and reveal conservation and divergence of gene expression balance across homoeologous subgenomes.

Benjamen White
Thomas Lux
Anthony Hall
ResearchOpen Access06 Oct 2025
Nature Communications

Volume: 16, P: 1-15
Toll-like receptor 8 senses degradation products of single-stranded RNA

Toll-like receptors (TLRs) have key roles in innate immunity. Here, Shimizu and colleagues report crystal structures of TLR8 in complex with single-stranded RNA that reveal the molecular basis for recognition of a natural ligand.

Hiromi Tanji
Umeharu Ohto
Toshiyuki Shimizu
Research19 Jan 2015
Nature Structural & Molecular Biology

Volume: 22, P: 109-115
Cloning and sequence analysis of calf cDNA and human genomic DNA encoding α-subunit precursor of muscle acetylcholine receptor

Masaharu Noda
Yasuji Furutani
Shosaku Numa
Research27 Oct 1983
Nature

Volume: 305, P: 818-823
Histopathological Study on Non-Aneurysmal Coronary Arteries in Kawasaki Disease

Kei Takahashi
Toshiaki Oharaseki
Megumi Wakayama
Research01 Jan 2003
Pediatric Research

Volume: 53, P: 186
Seasonal pigment fluctuation in diploid and polyploid Arabidopsis revealed by machine learning-based phenotyping method PlantServation

Long-term monitoring of plants in field fluctuating environments remains challenging. Here, the authors develop PlantServation, a machine learning-based phenotyping method, and estimate environmental and genotypic effects on the pigment anthocyanin content of diploid and polyploid Arabidopsis.

Reiko Akiyama
Takao Goto
Kentaro K. Shimizu
ResearchOpen Access22 Sept 2023
Nature Communications

Volume: 14, P: 1-16
Correction: Corrigendum: Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

Toshimasa Yamauchi
Junji Kamon
Takashi Kadowaki
Amendments and Corrections28 Oct 2004
Nature

Volume: 431, P: 1123
Multiple wheat genomes reveal global variation in modern breeding

Comparison of multiple genome assemblies from wheat reveals extensive diversity that results from the complex breeding history of wheat and provides a basis for further potential improvements to this important food crop.

Sean Walkowiak
Liangliang Gao
Curtis J. Pozniak
ResearchOpen Access25 Nov 2020
Nature

Volume: 588, P: 277-283
Design and validation of a method for evaluating medical device cleanliness by recovering and quantifying residual proteins on stainless plates

Miyuki Uematsu
Yuko Miyamoto
Eiichi Yamamoto
ResearchOpen Access20 Sept 2024
Scientific Reports

Volume: 14, P: 1-13
Human B-Cell Stimulatory Factor-2 Expressed in Escherichia Coli

Yoshihiro Asagoe
Kiyoshi Yasukawa
Mitsuaki Mitani
Research01 Jul 1988
Bio/Technology

Volume: 6, P: 806-809
Effects of dapagliflozin on myoglobin efflux from cardiomyocyte during myocardial ischemia/reperfusion in anesthetized rats

Tomohiro Hayashida
Yosuke Kuroko
Shingo Kasahara
ResearchOpen Access16 Jul 2024
Scientific Reports

Volume: 14, P: 1-8
Time to symptom onset and manual reduction outcomes as predictors of bowel viability in incarcerated obturator hernias

Yusuke Gokon
Yusuke Ohki
Koichiro Sato
ResearchOpen Access21 Jun 2024
Scientific Reports

Volume: 14, P: 1-5
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

Toshimasa Yamauchi
Junji Kamon
Takashi Kadowaki
Research12 Jun 2003
Nature

Volume: 423, P: 762-769
Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

Hideki Shimura
Nobutaka Hattori
Toshiaki Suzuki
Research01 Jul 2000
Nature Genetics

Volume: 25, P: 302-305
Domain-adaptive semi-supervised learning for efficient rare pathological lesion detection with minimal annotation

Isao Matsui
Ayumi Matsumoto
Yoshitaka Isaka
ResearchOpen Access23 Nov 2025
npj Digital Medicine

Volume: 8, P: 1-16
Effects of Dietary Sphingomyelin on Central Nervous System Myelination in Developing Rats

Kyoichi Oshida
Takashi Shimizu
Yuichiro Yamashiro
Research01 Apr 2003
Pediatric Research

Volume: 53, P: 589-593
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Kastor and Polluks polypeptides encoded by a single gene locus cooperatively regulate VDAC and spermatogenesis

A number of testes-specific lncRNAs have been annotated but their roles remain largely unexplored. Here the authors identify two small peptides encoded by the lncRNA Gm9999, Kastor and Polluks, both of which are required for male fertility in mice.

Shintaro Mise
Akinobu Matsumoto
Keiichi I. Nakayama
ResearchOpen Access28 Feb 2022
Nature Communications

Volume: 13, P: 1-17
Effect of Human Breast Milk on Urinary 8-Hydroxy-2′-Deoxyguanosine Excretion in Infants

Hiromichi Shoji
Satoshi Oguchi
Yuichiro Yamashiro
Research01 May 2003
Pediatric Research

Volume: 53, P: 850-852
Aldose reductase participates in the downregulation of T cell functions due to suppressor macrophages

Toshiaki Shimizu
Yutaka Tatano
Haruaki Tomioka
ResearchOpen Access12 Feb 2016
Scientific Reports

Volume: 6, P: 1-13
Na⁺-mimicking ligands stabilize the inactive state of leukotriene B₄ receptor BLT1

A structure of leukotriene B₄ receptor BLT1 bound with a benzamidine-containing compound, BIIL260, reveals an inverse-agonist mechanism involving ligand binding in the sodium ion-centered water cluster adjacent to the conserved orthosteric site of class A GPCRs.

Tetsuya Hori
Toshiaki Okuno
Shigeyuki Yokoyama
Research08 Jan 2018
Nature Chemical Biology

Volume: 14, P: 262-269
NO-inducible nitrosothionein mediates NO removal in tandem with thioredoxin

The metallothionein-like, 23-amino-acid peptide NO-inducible nitrosothionein does not protect against heavy metal toxicity like its homologues, but instead helps relieve nitrosative stress by reaction of six cysteine residues to form SNO adducts, which are recycled back to thiols by thioredoxin.

Shengmin Zhou
Toshiaki Narukami
Naoki Takaya
Research18 Aug 2013
Nature Chemical Biology

Volume: 9, P: 657-663
Robotic crowd biology with Maholo LabDroids

Nozomu Yachie
Koichi Takahashi
Tohru Natsume
Correspondence11 Apr 2017
Nature Biotechnology

Volume: 35, P: 310-312
Selective and Potent in Vitro Antitrypanosomal Activities of Ten Microbial Metabolites

Kazuhiko Otoguro
Aki Ishiyama
Satoshi Ōmura
Research01 Jun 2008
The Journal of Antibiotics

Volume: 61, P: 372-378
Effect of febuxostat on left ventricular diastolic function in patients with asymptomatic hyperuricemia: a sub analysis of the PRIZE Study

Kenya Kusunose
Hisako Yoshida
Mikiko Kagiyama
ResearchOpen Access17 Oct 2021
Hypertension Research

Volume: 45, P: 106-115
Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial

Kazunori Toyoda
Masatoshi Koga
Hiroaki Tanaka
ResearchOpen Access09 Jul 2024
Hypertension Research

Volume: 47, P: 2238-2249
Selective Increase of Vβ2⁺ T Cells in the Small Intestinal Mucosa in Kawasaki Disease

Yuichiro Yamashiro
Satoru Nagata
Toshiaki Shimizu
Research01 Feb 1996
Pediatric Research

Volume: 39, P: 264-266
TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells

Antiviral immune responses involve clustering of plasmacytoid dendritic cells (pDC) in response to endosomal TLR7-mediated sensing of viral RNA. Here the authors show the GTPase Arl8b controls translocation of TLR7⁺ endosomes to the periphery of the cell via microtubule interactions, thus enabling pDC clustering and type I interferon production.

Shin-Ichiroh Saitoh
Fumiko Abe
Kensuke Miyake
ResearchOpen Access17 Nov 2017
Nature Communications

Volume: 8, P: 1-12
Visit-to-visit variability of blood pressure and cardiovascular events among the working-age population in Japan: findings from the Japan Epidemiology Collaboration on Occupational Health Study

Yosuke Inoue
Keisuke Kuwahara
Rika Osawa
Research14 May 2021
Hypertension Research

Volume: 44, P: 1017-1025
Linkage and haplotype analysis of familial early-onset Alzheimer disease in Japanese population

Kouzin Kamino
Keiko Nagano
Toshio Ogihara
Research01 Sept 1995
Japanese journal of human genetics

Volume: 40, P: 229-241
New Insight into the Role of the Calvin Cycle: Reutilization of CO₂ Emitted through Sugar Degradation

Rie Shimizu
Yudai Dempo
Toshiaki Fukui
ResearchOpen Access01 Jul 2015
Scientific Reports

Volume: 5, P: 1-12
Protective Effects of Mizoribine on Cyclosporine A Nephropathy in Rats

Satoshi Hara
Daisuke Umino
Toshiaki Shimizu
Research01 Nov 2009
Pediatric Research

Volume: 66, P: 524-527
Importance of EQA/PT for the detection of genetic variants in comprehensive cancer genome testing

Kazuyuki Matsushita
Takayuki Ishige
Hirotaka Matsui
ResearchOpen Access07 Jan 2025
Scientific Reports

Volume: 15, P: 1-12
Incongruent pitch cues are associated with increased activation and functional connectivity in the frontal areas

Jo-Fu Lotus Lin
Toshiaki Imada
Fa-Hsuan Lin
ResearchOpen Access26 Mar 2018
Scientific Reports

Volume: 8, P: 1-12
A COL4A1 variant in a neonate with multiple intracranial hemorrhages and congenital cataracts

Ayane Yakabe
Tamaki Ikuse
Toshiaki Shimizu
ResearchOpen Access10 Jun 2022
Human Genome Variation

Volume: 9, P: 1-3
Evaluation of the use of non-invasive hemoglobin measurement in early childhood

Yoshiteru Arai
Hiromichi Shoji
Toshiaki Shimizu
Research29 Jul 2022
Pediatric Research

Volume: 93, P: 1036-1040
Short-duration part-time light work and real-time blood pressure variability in older adults: a pilot observational study using cuffless technology at Expo 2025 Osaka

Taisuke Ueno
Yoichi Takami
Koichi Yamamoto
Correspondence20 Aug 2025
Hypertension Research

Volume: 48, P: 3057-3058
Hydrogen-rich water reduced oxidative stress and renal fibrosis in rats with unilateral ureteral obstruction

Akira Mizutani
Amane Endo
Toshiaki Shimizu
Research07 Aug 2021
Pediatric Research

Volume: 91, P: 1695-1702
Evaluation of kidney dysfunction and angiotensinogen as an early novel biomarker of intrauterine growth restricted offspring rats

Yayoi Murano
Naoto Nishizaki
Toshiaki Shimizu
Research13 Aug 2015
Pediatric Research

Volume: 78, P: 678-682
Reducing Cell Membrane n-6 Fatty Acids Attenuate Mucosal Damage in Food-Sensitive Enteropathy in Mice

Yoshikazu Ohtsuka
Yuichiro Yamashiro
Keijiro Yabuta
Research01 Dec 1997
Pediatric Research

Volume: 42, P: 835-839
Effects of Iron-Unsaturated Human Lactoferrin on Hydrogen Peroxide-Induced Oxidative Damage in Intestinal Epithelial Cells

Hiromichi Shoji
Satoshi Oguchi
Yuichiro Yamashiro
Research01 Jan 2007
Pediatric Research

Volume: 61, P: 89-92
Systematic molecular analyses of SHOX in Japanese patients with idiopathic short stature and Leri–Weill dyschondrosteosis

Hirohito Shima
Toshiaki Tanaka
M Fukami
Research17 Mar 2016
Journal of Human Genetics

Volume: 61, P: 585-591
Microbiologic Studies on the Small Intestine in Kawasaki Disease

Yuichiro Yamashiro
Satoru Nagata
Toshiaki Shimizu
Research01 Apr 1996
Pediatric Research

Volume: 39, P: 622-624
Effects of Bifidobacterium breve on inflammatory gene expression in neonatal and weaning rat intestine

Yoshikazu Ohtsuka
Takako Ikegami
Toshiaki Shimizu
Research15 Dec 2011
Pediatric Research

Volume: 71, P: 46-53
Synergistic protective effects of mizoribine and angiotensin II receptor blockade on cyclosporine A nephropathy in rats

Amane Endo
Tomonosuke Someya
Toshiaki Shimizu
Research11 Oct 2013
Pediatric Research

Volume: 75, P: 38-44
Chronic Oral Antigen Exposure Induces Lymphocyte Migration in Anaphylactic Mouse Intestine

Yoshikazu Ohtsuka
Ryuyo Suzuki
Chisei Ra
Research01 Nov 1998
Pediatric Research

Volume: 44, P: 791-797

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