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Recurrent evolutionary switches of mitochondrial cytochrome c maturation systems in Archaeplastida

Cytochrome c maturation (CCM) is the process of covalent attachment of a heme group to the conserved cysteines to form the holocytochrome. Here, the authors report that the non-adaptive convergent evolution at the pathway level leads to mosaic distribution of CCM systems I and III among Archaeplastida species.

Huang Li
Soujanya Akella
Jeffrey P. Mower
ResearchOpen Access20 Feb 2024
Nature Communications

Volume: 15, P: 1-13
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Genome of Paspalum vaginatum and the role of trehalose mediated autophagy in increasing maize biomass

Paspalum vaginatum is a stress tolerant wild relative of maize and sorghum. Here, the authors assemble its genome at pseudomolecule level and reveal the role of trehalose mediated autophagy in increasing maize biomass productivity under nutrient-deficit conditions.

Guangchao Sun
Nishikant Wase
James C. Schnable
ResearchOpen Access13 Dec 2022
Nature Communications

Volume: 13, P: 1-20
ACC1 determines memory potential of individual CD4⁺ T cells by regulating de novo fatty acid biosynthesis

ACC1 is a rate-limiting enzyme during fatty acid biosynthesis. Here the authors describe how loss of ACC1 enhances CD4⁺ memory T cell formation and improves outcome in a murine model of parasite infection, indicating that lipid biosynthesis directs cell-fate determination during the generation of memory T cells.

Yusuke Endo
Atsushi Onodera
Toshinori Nakayama
Research14 Jan 2019
Nature Metabolism

Volume: 1, P: 261-275
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Protein-protein interactions and metabolite channelling in the plant tricarboxylic acid cycle

A metabolon is a complex of sequential metabolic enzymes that channels substrates directly between enzymes, thus optimizing metabolic flux. Here Zhanget al. provide protein interaction and isotope dilution data that support the existence of a metabolon that channels both citrate and fumarate in the plant TCA cycle.

Youjun Zhang
Katherine F. M. Beard
Toshihiro Obata
ResearchOpen Access16 May 2017
Nature Communications

Volume: 8, P: 1-11
Elevated Plasma Brain Natriuretic Peptide Levels Independent of Heart Disease in Acute Ischemic Stroke: Correlation with Stroke Severity

Hirofumi Tomita
Norifumi Metoki
Ken Okumura
Research01 Sept 2008
Hypertension Research

Volume: 31, P: 1695-1702
Early detection of pancreatic cancer by comprehensive serum miRNA sequencing with automated machine learning

Munenori Kawai
Akihisa Fukuda
Hiroshi Seno
ResearchOpen Access28 Aug 2024
British Journal of Cancer

Volume: 131, P: 1158-1168
Novel mutations in five Japanese patients with 3-methylcrotonyl-CoA carboxylase deficiency

Mitsugu Uematsu
Osamu Sakamoto
Toshihiro Ohura
Research30 Oct 2007
Journal of Human Genetics

Volume: 52, P: 1040-1043
Engineered protein subunit COVID19 vaccine is as immunogenic as nanoparticles in mouse and hamster models

Melissa M. Matthews
Tae Gyun Kim
Matthias Wolf
ResearchOpen Access26 Oct 2024
Scientific Reports

Volume: 14, P: 1-14
Charge mobility calculation of organic semiconductors without use of experimental single-crystal data

Hiroyuki Ishii
Shigeaki Obata
Jun Takeya
ResearchOpen Access17 Feb 2020
Scientific Reports

Volume: 10, P: 1-10
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14
Association of the malate dehydrogenase-citrate synthase metabolon is modulated by intermediates of the Krebs tricarboxylic acid cycle

Joy Omini
Izabela Wojciechowska
Toshihiro Obata
ResearchOpen Access21 Sept 2021
Scientific Reports

Volume: 11, P: 1-10
FLT3-ITD transduces autonomous growth signals during its biosynthetic trafficking in acute myelogenous leukemia cells

Kouhei Yamawaki
Isamu Shiina
Yuuki Obata
ResearchOpen Access22 Nov 2021
Scientific Reports

Volume: 11, P: 1-12
Synthetic analogues of 2-oxo acids discriminate metabolic contribution of the 2-oxoglutarate and 2-oxoadipate dehydrogenases in mammalian cells and tissues

Artem V. Artiukhov
Aneta Grabarska
Victoria I. Bunik
ResearchOpen Access05 Feb 2020
Scientific Reports

Volume: 10, P: 1-22
Identification of serum metabolome signatures associated with retinal and renal complications of type 2 diabetes

Tomofuji et al. perform non-targeted metabolomics on serum samples from people with type 2 diabetes with or without complications. The authors identify metabolites associated with retinal and renal complications.

Yoshihiko Tomofuji
Ken Suzuki
Takashi Kadowaki
ResearchOpen Access09 Jan 2023
Communications Medicine

Volume: 3, P: 1-8

Search

Recurrent evolutionary switches of mitochondrial cytochrome c maturation systems in Archaeplastida

DOCK2 is involved in the host genetics and biology of severe COVID-19

Genome of Paspalum vaginatum and the role of trehalose mediated autophagy in increasing maize biomass

ACC1 determines memory potential of individual CD4⁺ T cells by regulating de novo fatty acid biosynthesis

Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Protein-protein interactions and metabolite channelling in the plant tricarboxylic acid cycle

Elevated Plasma Brain Natriuretic Peptide Levels Independent of Heart Disease in Acute Ischemic Stroke: Correlation with Stroke Severity

Early detection of pancreatic cancer by comprehensive serum miRNA sequencing with automated machine learning

Novel mutations in five Japanese patients with 3-methylcrotonyl-CoA carboxylase deficiency

Engineered protein subunit COVID19 vaccine is as immunogenic as nanoparticles in mouse and hamster models

Charge mobility calculation of organic semiconductors without use of experimental single-crystal data

Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Association of the malate dehydrogenase-citrate synthase metabolon is modulated by intermediates of the Krebs tricarboxylic acid cycle

FLT3-ITD transduces autonomous growth signals during its biosynthetic trafficking in acute myelogenous leukemia cells

Synthetic analogues of 2-oxo acids discriminate metabolic contribution of the 2-oxoglutarate and 2-oxoadipate dehydrogenases in mammalian cells and tissues

Identification of serum metabolome signatures associated with retinal and renal complications of type 2 diabetes

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