The p53-inducible antiproliferative gene BTG2 is suppressed in many cancers, in the absence of inactivating gene mutations. Here the authors show that the histone lysine methyltransferase SETD1A suppresses the expression of several p53 target genes including BTG2by inducing a network of microRNAs.
- Ken Tajima
- Toshifumi Yae
- Shyamala Maheswaran
