Nature Search

A single-chain antibody generation system yielding CAR-T cells with superior antitumor function

With the aim of optimizing CAR-T cells for immunotherapy, Ochi et al. have established a system to generate and screen a library of CAR-T cells expressing different immunoglobulin variable regions. They show that this approach can enhance anti-tumour activities of CAR-T cells in vivo.

Toshiki Ochi
Masaki Maruta
Masaki Yasukawa
ResearchOpen Access02 Mar 2021
Communications Biology

Volume: 4, P: 1-13
HLA-DP^84Gly constitutively presents endogenous peptides generated by the class I antigen processing pathway

MHC class I and II molecules generally present endogenous and exogenous peptides, respectively, through distinct mechanisms. Here, the authors show that the class II molecule HLA-DP^84Glyuses both class I and II mechanisms to constitutively present peptides.

Yuki Yamashita
Mark Anczurowski
Naoto Hirano
ResearchOpen Access10 May 2017
Nature Communications

Volume: 8, P: 1-14
Direct comparison of target-reactivity and cross-reactivity induced by CAR- and BiTE-redirected T cells for the development of antibody-based T-cell therapy

Masaki Maruta
Toshiki Ochi
Masaki Yasukawa
ResearchOpen Access16 Sept 2019
Scientific Reports

Volume: 9, P: 1-13
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Polygenic risk scores for major psychiatric and neurodevelopmental disorders contribute to sleep disturbance in childhood: Adolescent Brain Cognitive Development (ABCD) Study

Kazutaka Ohi
Ryo Ochi
Shinichiro Nakajima
ResearchOpen Access26 Mar 2021
Translational Psychiatry

Volume: 11, P: 1-11
Mechanisms underlying the lack of endogenous processing and CLIP-mediated binding of the invariant chain by HLA-DP^84Gly

Mark Anczurowski
Yuki Yamashita
Naoto Hirano
ResearchOpen Access19 Mar 2018
Scientific Reports

Volume: 8, P: 1-13
CD4⁺ and CD8⁺ TCRβ repertoires possess different potentials to generate extraordinarily high-avidity T cells

Munehide Nakatsugawa
Muhammed A. Rahman
Naoto Hirano
ResearchOpen Access31 Mar 2016
Scientific Reports

Volume: 6, P: 1-15
Altered T cell phenotypes associated with clinical relapse of multiple sclerosis patients receiving fingolimod therapy

Chihiro Fujii
Takayuki Kondo
Toshiki Mizuno
ResearchOpen Access18 Oct 2016
Scientific Reports

Volume: 6, P: 1-14
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14
Predictors of early remission of proteinuria in adult patients with minimal change disease: a retrospective cohort study

Ryohei Yamamoto
Enyu Imai
Hiroyuki Komatsu
ResearchOpen Access13 Jun 2022
Scientific Reports

Volume: 12, P: 1-12

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