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Showing 1–6 of 6 results
Advanced filters: Author: Toyoyuki Ose Clear advanced filters
  • HIV replication has been shown previously to be inhibited by combinations of T cells and NK cells according to HLA and KIR haplotype. Here the authors consider a combination of KIR2DL2+ NK and HLA-C*12:02-restricted T cells and clarify how a specific HIV pol escape mutant facilitates virus control by KIR2DL2+ NK cells.

    • Takayuki Chikata
    • Kimiko Kuroki
    • Masafumi Takiguchi
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16
  • The measles virus hemagglutinin (MVH) promotes viral attachment to host cells via interaction with signaling lymphocyte activation molecule (SLAM). Now the crystal structure of MVH head domain in complex with the distal domain of SLAM, together with functional work, reveals the details of this interaction and explains the effectiveness of the currently used vaccine.

    • Takao Hashiguchi
    • Toyoyuki Ose
    • Yusuke Yanagi
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 135-141
  • The MILL (MHC-I-like located near the leukocyte receptor complex) family is a group of related nonclassical MHC-I molecules. Here the authors present the crystal structure of MILL2, which reveals an unusual interdomain flexibility, and show that MILL2 binds heparan sulfate on the surface of fibroblasts through a basic patch.

    • Mizuho Kajikawa
    • Toyoyuki Ose
    • Katsumi Maenaka
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-9
  • Roquin is an RNA-binding protein that promotes the degradation of specific mRNAs and is crucial for the maintenance of peripheral immune tolerance. Here the authors show that, in addition to its target mRNAs, Roquin can bind miR-146a and the RISC component Ago2 to control homeostasis of both RNA species.

    • Monika Srivastava
    • Guowen Duan
    • Carola G. Vinuesa
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-13