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Showing 1–7 of 7 results
Advanced filters: Author: Tracy Ballinger Clear advanced filters

  • This is an issue edsumm for ng1929. Identification of the Palaeocene/Eocene thermal maximum in a marine sedimentary sequence. It shows that sea surface temperatures near the North Pole increased from roughly 18 degrees Celsius to over 23 degrees Celsius — such warm values imply the absence of ice and thus exclude the influence of ice-albedo feedbacks on this Arctic warming.

    • Daniel Zilberman
    • Mary Gehring
    • Steven Henikoff
    Research
    Nature Genetics
    Volume: 39, P: 61-69

  • Previous work has identified several genes where mutations lead to breast cancer, but other genetic and environmental factors must still be accounted for. A large study of genetic association with breast cancer points to four novel genes and many more genetic markers that should be pursued for their link to cancer susceptibility.

    • Douglas F. Easton
    • Karen A. Pooley
    • Bruce A. J. Ponder
    Research
    Nature
    Volume: 447, P: 1087-1093

  • This study describes the integrative analysis of 111 reference human epigenomes, profiled for histone modification patterns, DNA accessibility, DNA methylation and RNA expression; the results annotate candidate regulatory elements in diverse tissues and cell types, their candidate regulators, and the set of human traits for which they show genetic variant enrichment, providing a resource for interpreting the molecular basis of human disease.

    • Anshul Kundaje
    • Wouter Meuleman
    • Manolis Kellis
    ResearchOpen Access
    Nature
    Volume: 518, P: 317-330

  • The methylation of DNA in 5′ promoter regions suppresses gene expression, but what is the role of DNA methylation in the bodies of genes? Here, a map of DNA methylation is generated from human brain tissue; it is found that most methylated CpG islands are within intragenic and intergenic regions, rather than within promoters. It is proposed that intragenic methylation regulates the expression of alternative gene transcripts in different tissues and cell types.

    • Alika K. Maunakea
    • Raman P. Nagarajan
    • Joseph F. Costello
    Research
    Nature
    Volume: 466, P: 253-257

  • Methods for profiling DNA methylation differ in the physical principles used to detect modified cytosines. Harris et al. compare the performances of four sequencing-based technologies for genome-wide analysis of DNA methylation and combine two methods to enable detection of allelic differences in epigenetic marks.

    • R Alan Harris
    • Ting Wang
    • Joseph F Costello
    Research
    Nature Biotechnology
    Volume: 28, P: 1097-1105