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Showing 1–3 of 3 results
Advanced filters: Author: Trevor Shew Clear advanced filters

  • Bats harbor diverse viruses but it’s less clear how they tolerate infection. Here, by characterizing innate immune responses in bat cells the authors show that IFN-beta signaling resists antagonistic activity by viruses and identify interferon stimulated genes with enhanced antiviral activity.

    • Victoria Gonzalez
    • Briallen Lobb
    • Arinjay Banerjee
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Genetic variants in CD36 have been associated with metabolic syndrome. Here, the authors found that lymphatic vessel integrity and lipid transport are influenced by CD36 expression, and lymphatic endothelial cell CD36 deficiency causes visceral obesity and insulin resistance, which are risk factors for metabolic syndrome and diabetes.

    • Vincenza Cifarelli
    • Sila Appak-Baskoy
    • Nada A. Abumrad
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • Impaired myocardial metabolic flexibility is associated with cardiac dysfunction in diabetes and heart failure. McCommis et al. reveal a critical role for mitochondrial pyruvate use in cardiac function, and use dietary interventions to enhance cardiac fat metabolism in dilated cardiomyopathy.

    • Kyle S. McCommis
    • Attila Kovacs
    • Brian N. Finck
    Research
    Nature Metabolism
    Volume: 2, P: 1232-1247