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Showing 1–4 of 4 results
Advanced filters: Author: Tristan J. Dodds Clear advanced filters

  • Mucosal melanomas are challenging to treat partly because so little is known about the genetic drivers underpinning them. Here, the authors perform a genomic landscape analysis of samples collected from three continents, revealing a potential role for CDK4/6 or MEK inhibition in the treatment of the disease.

    • Felicity Newell
    • Yan Kong
    • Richard A. Scolyer
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • Acral melanoma occurs on the soles of the feet, palms of the hands and in nail beds. Here, the authors reports the genomic landscape of 87 acral melanomas and find that some tumors harbor a UV signature and that the tumors are diverse at the levels of mutational signatures, structural aberrations and copy number signatures.

    • Felicity Newell
    • James S. Wilmott
    • Nicholas K. Hayward
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14