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Showing 1–8 of 8 results
Advanced filters: Author: Tristan de Rond Clear advanced filters

  • A genome-mining approach targeted to enzyme domains that co-occur in a single protein (CO-ED) facilitates the discovery and characterization of an oxazolone synthetase involved in the biosynthesis of a series of oxazolone-containing natural products.

    • Tristan de Rond
    • Julia E. Asay
    • Bradley S. Moore
    Research
    Nature Chemical Biology
    Volume: 17, P: 794-799

  • A natural product containing an acylsulfenic acid functional group was discovered in a marine Streptomyces bacterium. Its biosynthesis is orchestrated by enzymes from both primary and secondary metabolism, including a flavin-dependent S-hydroxylase. The prevalence of enzymes catalysing the production of acylsulfenic acid in bacteria implies a potentially broad distribution of this functional group in specialized metabolites.

    • Dan Xue
    • Hongbin Zou
    • Jie Li
    Research
    Nature Chemistry
    Volume: 17, P: 1011-1019

  • Marine natural products are often made by symbiotic microbes, but octocorals encode their own terpene cyclases that share features with bacterial versions and produce terpenoid precursors, including the coral-exclusive capnellane scaffold.

    • Immo Burkhardt
    • Tristan de Rond
    • Bradley S. Moore
    Research
    Nature Chemical Biology
    Volume: 18, P: 664-669

  • In Pseudoalteromonas rubra, an unclustered biosynthetic gene encodes a di-iron oxygenase-like enzyme that catalyzes regiospecific C–H activation and cyclization of prodigiosin, yet is unrelated to the Rieske oxygenases that produce other cyclized prodiginines.

    • Tristan de Rond
    • Parker Stow
    • Jay D Keasling
    Research
    Nature Chemical Biology
    Volume: 13, P: 1155-1157

  • Advances in computational omics technologies are enabling access to the hidden diversity of natural products, and artificial intelligence approaches are facilitating key steps in harnessing the therapeutic potential of such compounds, including biological activity prediction. This article discusses synergies between these fields to effectively identify drug candidates from the plethora of molecules produced by nature, and how to address the challenges in realizing the potential of these synergies.

    • Michael W. Mullowney
    • Katherine R. Duncan
    • Marnix H. Medema
    Reviews
    Nature Reviews Drug Discovery
    Volume: 22, P: 895-916

  • Genomics and metabolomics are widely used to explore specialized metabolite diversity. The Paired Omics Data Platform is a community initiative to systematically document links between metabolome and (meta)genome data, aiding identification of natural product biosynthetic origins and metabolite structures.

    • Michelle A. Schorn
    • Stefan Verhoeven
    • Justin J. J. van der Hooft
    Comments & OpinionOpen Access
    Nature Chemical Biology
    Volume: 17, P: 363-368

  • Omics methods can be used to mine the genomes of diverse organisms, from microorganisms to plants and animals, for the discovery of natural products and their biosynthetic genes. In this Review, the authors review the why, what, where and how of genome mining.

    • Marnix H. Medema
    • Tristan de Rond
    • Bradley S. Moore
    Reviews
    Nature Reviews Genetics
    Volume: 22, P: 553-571