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Showing 1–12 of 12 results
Advanced filters: Author: Troels Skrydstrup Clear advanced filters

  • While CO2 can be converted to CO for further reactivity, typically this involves the generation of large amounts of waste. Here the authors report the conversion of CO2to CO, with the siloxane by-product being further used in a carbonylative Hiyama-Denmark coupling to form diarylketones.

    • Zhong Lian
    • Dennis U. Nielsen
    • Troels Skrydstrup
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-7

  • The incorporation of multiple carbon labels into drug candidates is a difficult synthetic challenge. Here an operationally simple method for the preparation of multi-carbon-labelled isotopologues of active pharmaceutical ingredients and other bioactive molecules, through a combined catalytic three-gas surrogate hydroformylation strategy, is reported.

    • Hans Christian D. Hammershøj
    • Haraldur G. Gudmundsson
    • Troels Skrydstrup
    Research
    Nature Synthesis
    Volume: 2, P: 243-250

  • CO is a vital building block in organic synthesis but, due to its toxicity, storage and transport can be problematic. This review focuses on the methods — both chemical and electrochemical — for the in situ generation of CO from CO2, and its subsequent incorporation into chemicals through catalytic means.

    • Dennis U. Nielsen
    • Xin-Ming Hu
    • Troels Skrydstrup
    Reviews
    Nature Catalysis
    Volume: 1, P: 244-254

  • The poor bench stability of phosphoramidites is a drawback for fast automised chemical oligonucleotide synthesis. Here, the authors report a method for on-demand flow synthesis of phosphoramidites within short reaction times, in near-quantitative yields and sufficient purity for integration with DNA synthesizers.

    • Alexander F. Sandahl
    • Thuy J. D. Nguyen
    • Kurt V. Gothelf
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-7

  • Hydroformylation of alkenes is widely used in industry to synthesize aldehydes, but is less prominent in small laboratories due to safety and equipment issues associated with the CO/H2 mixture. This is now addressed by generating stoichiometric syngas from two main element compounds, with water as the activator.

    • Samuel K. Pedersen
    • Haraldur G. Gudmundsson
    • Troels Skrydstrup
    Research
    Nature Catalysis
    Volume: 3, P: 843-850

  • Electroreduction of CO2 to CO is a potential valorisation pathway of carbon dioxide for fine chemicals production. Here, the authors show a user-friendly device that couples CO2 electroreduction with carbonylation chemistry for up to gram scale synthesis of pharmaceuticals even under atmospheric CO2.

    • Mikkel T. Jensen
    • Magnus H. Rønne
    • Troels Skrydstrup
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-8

  • Positron emission tomography is widely used to diagnose and monitor different disease states and interest in the technique has led to the demand for the development of new method for radiolabelling. Here the authors review the recent progress in the development of new PET probes.

    • Jian Rong
    • Achi Haider
    • Steven H. Liang
    ReviewsOpen Access
    Nature Communications
    Volume: 14, P: 1-23

  • The direct carbon isotope exchange reaction on α-amino acids is highly desirable, as existing labelling methods require several synthetic steps and harsh conditions. Now, an aldehyde-catalysed carboxylate exchange with isotopically labelled *CO2 has enabled the direct formation of 11C, 13C and 14C-labelled α-amino acids.

    • Karoline T. Neumann
    • Troels Skrydstrup
    News & Views
    Nature Chemistry
    Volume: 14, P: 1339-1340

  • Ruthenium complexes with facially coordinating tripodal phosphine ligands are privileged catalysts for a broad range of (de-)hydrogenation-based transformations but the mechanism remains poorly understood. Here the authors present a detailed investigation on the triphos-Ru catalysed C–O bond scission on a molecular level.

    • Alexander Ahrens
    • Gabriel Martins Ferreira Batista
    • Troels Skrydstrup
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-10

  • Carbon isotope labelling of bioactive molecules is essential for accessing the pharmacokinetic and pharmacodynamic properties of new drug entities. Here, the authors propose an electrochemical isotope-labelling protocol which enables the use of near-stoichiometric 14CO2, facilitating late-stage and single-step carbon-14 labelling of pharmaceuticals and representative precursors.

    • Gabriel M. F. Batista
    • Ruth Ebenbauer
    • Troels Skrydstrup
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-10

  • The authors report a transition-metal-catalysed protocol for recovery of polymer building block bisphenol  A and intact fibres from epoxy composites, demonstrating that chemical recycling approaches for thermoset epoxy resins and composites are achievable.

    • Alexander Ahrens
    • Andreas Bonde
    • Troels Skrydstrup
    ResearchOpen Access
    Nature
    Volume: 617, P: 730-737