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Showing 1–3 of 3 results
Advanced filters: Author: Trond Lamark Clear advanced filters

  • Using in vitro reconstitution systems, three studies shed light on the interactions of Atg8 family proteins with cargo receptors and components of the basal autophagy machinery. The results have important mechanistic implications for selective macroautophagy, scaffold formation and spatio-temporal organization of the lipidation process during autophagosome formation.

    • Terje Johansen
    • Trond Lamark
    News & Views
    Nature Cell Biology
    Volume: 16, P: 395-397

  • PB1-mediated oligomerization of p62/SQSTM1 is essential for its function as a selective autophagy receptor. Here the authors present the cryo-EM structures of human and Arabidopsis PB1 domain helical assemblies and find that a conserved double arginine finger in the PB1 domain is important for p62 polymerisation and lysosomal targeting of p62.

    • Arjen J. Jakobi
    • Stefan T. Huber
    • Carsten Sachse
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • In response to cancer-associated stress, autophagy machinery mediates degradation of nuclear lamina components in mammals, suggesting that cells might degrade nuclear components to prevent tumorigenesis.

    • Zhixun Dou
    • Caiyue Xu
    • Shelley L. Berger
    Research
    Nature
    Volume: 527, P: 105-109