Thi Lieu Dang et al. study the mechanisms for the interaction between DGCR8 and the apical UGU motif of pri-miRNAs. They demonstrate that three amino acids in the Rhed domain of DGCR8 are critical to recognize and interact with UGU and to process pri-miRNAs. They further show amino acids 461–463 in one of the DGCR8 dimer are necessary to distinguish UGU- and noUGU-primiRNAs.
- Thi Lieu Dang
- Cong Truc Le
- Tuan Anh Nguyen
